Title :

Cyclophosphamide versus Etoposide in Combination with Total Body Irradiation as Conditioning Regimen for Adult Patients with Ph-negative Acute Lymphoblastic Leukemia Undergoing Allogeneic Stem Cell Transplant: On behalf of the ALWP of the EBMT.

Author(s) :

Czyz, Anna [Auteur]
Labopin, Myriam [Auteur]
Giebel, Sebastian [Auteur]
Socie, Gerard [Auteur]
Apperley, Jane [Auteur]
Volin, Liisa [Auteur]
Remenyi, Peter [Auteur]
Yakoub-Agha, Ibrahim [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Orchard, Kim [Auteur]
Michallet, Mauricette [Auteur]
Stuhler, Gernot [Auteur]
Chaganti, Sridhar [Auteur]
Murray, Martin [Auteur]
Aljurf, Mahmoud [Auteur]
Bloor, Adrian [Auteur]
Passweg, Jakob [Auteur]
Finke, Jurgen [Auteur]
Mohty, Mohamad [Auteur]
Nagler, Arnon [Auteur]

Journal title :

American journal of hematology

Abbreviated title :

Am. J. Hematol.

Publication date :

2018-03-25

ISSN :

1096-8652

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Allogeneic hematopoietic cell transplantation (alloHCT) with myeloablative conditioning based on total body irradiation (TBI) is widely used for the treatment of adults with acute lymphoblastic leukemia (ALL). TBI is ...
Show more >Allogeneic hematopoietic cell transplantation (alloHCT) with myeloablative conditioning based on total body irradiation (TBI) is widely used for the treatment of adults with acute lymphoblastic leukemia (ALL). TBI is most frequently administered in combination with either cyclophosphamide (Cy/TBI) or etoposide (Vp/TBI). The goal of this study was to retrospectively compare these two regimens. Adult patients with Ph-negative ALL treated with alloHCT in first or second complete remission who received Cy/TBI (n = 1346) or Vp/TBI (n = 152) conditioning were included in the analysis. In a univariate analysis, as compared to Cy/TBI, the use of Vp/TBI was associated with reduced incidence of relapse (17% vs. 30% at 5 years, P = .007), increased rate of leukemia-free survival (60% vs. 50%, P = .04), and improvedShow less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Inserm
Université de Lille
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Research team(s) :

Immunity, inflammation and fibrsis in auto and allo-reactivity

Submission date :

2019-03-01T14:17:55Z