Title :

miR-21-5p renal expression is associated with fibrosis and renal survival in patients with IgA nephropathy

Author(s) :

Buob, David [Auteur]
Van Der Hauwaert, Cynthia [Auteur]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Gnemmi, Viviane [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Jomaa, Zacharie [Auteur]
Pottier, Nicolas [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - EA 4483
Savary, Gregoire [Auteur]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Drumez, Elodie [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Noel, Christian [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
Cauffiez, Christelle [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - EA 4483
Glowacki, Francois [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - EA 4483

Journal title :

Scientific Reports

Abbreviated title :

Sci Rep

Volume number :

6

Pages :

27209

Publisher :

Nature Publishing Group

Publication date :

2016-06-06

ISSN :

2045-2322

HAL domain(s) :

Sciences du Vivant [q-bio]
Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Urologie et Néphrologie

English abstract : [en]

IgA nephropathy (IgAN) is the most prevalent primary glomerulonephritis, whose prognosis is highly variable. Interstitial fibrosis is a strong independent prognosis factor. Among microRNA involved in renal fibrogenesis, ...
Show more >IgA nephropathy (IgAN) is the most prevalent primary glomerulonephritis, whose prognosis is highly variable. Interstitial fibrosis is a strong independent prognosis factor. Among microRNA involved in renal fibrogenesis, only few have been investigated in IgAN. In the context of IgAN, we aimed to analyze the role of miR-21-5p, miR-214-3p and miR-199a-5p, three established “fibromiRs” involved in renal fibrosis. Fifty-six IgAN biopsy specimens were retrospectively scored according to Oxford classification. Renal expression of miR-21-5p, miR-214-3p and miR-199a-5p were significantly associated with T score (miR-21-5p T0 RQ median = 1.23, T1 RQ = 3.01, T2 RQ = 3.90; miR-214-5p T0 RQ = 1.39, T1 RQ = 2.20, T2 RQ = 2.48; miR-199a-5p T0 RQ = 0.76, T1 RQ = 1.41, T2 RQ = 1.87). miR-21-5p expression was associated with S score (S0 RQ median = 1.31, S1 RQ = 2.65), but not miR-214-3p nor miR-199a-5p. In our cohort, poor renal survival was associated with high blood pressure, proteinuria and elevated creatininemia, as well as T and S scores. Moreover, renal expression of miR-21-5p, miR-214-3p were associated with renal survival. In conclusion, miR-21-5p, miR-214-3p and miR-199a-5p are three “fibromiRs” involved in renal fibrosis in the course of IgAN and miR-21-5p and miR-214-3p are associated with renal survival.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Other project(s) or funding source(s) :

Santelys association
CHRU Lille

Administrative institution(s) :

Inserm
Université de Lille
CHU Lille
Institut Pasteur de Lille

Collections :

• IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
• Lille Neurosciences & Cognition (LilNCog) - U 1172
• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Research team(s) :

Immunity, inflammation and fibrsis in auto and allo-reactivity

Submission date :

2019-03-01T14:25:37Z
2021-05-17T07:39:51Z
2024-02-20T14:13:37Z