Title :

Hydroxychloroquine-induced hearing loss: First case of positive rechallenge and analysis of the French pharmacovigilance database.

Author(s) :

Chatelet, J-N [Auteur]
Auffret, M [Auteur]
Combret, S [Auteur]
Bondon-Guitton, E [Auteur]
Lambert, Marc [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
Lille Inflammation Research International Center (LIRIC) - U995
Gautier, Sophie [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 [TCDV]

Journal title :

La Revue de medecine interne

Abbreviated title :

Rev. Med. Interne

Volume number :

38

Pages :

340-343

Publication date :

2017-05-01

ISSN :

1768-3122
1768-3122

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

BACKGROUND: Several cases of hearing loss induced by hydroxychloroquine have been reported in the literature but the role of hydroxychloroquine still remains debated. METHODS: We report the first case, to our knowledge, ...
Show more >BACKGROUND: Several cases of hearing loss induced by hydroxychloroquine have been reported in the literature but the role of hydroxychloroquine still remains debated. METHODS: We report the first case, to our knowledge, of hearing loss induced by hydroxychloroquine with a positive re challenge in a woman treated for systemic lupus. An analysis of the French pharmacovigilance database allowed to identify 23 additional cases of hearing loss in patients treated with hydroxychloroquine and, among them, 8 had systemic lupus. CONCLUSIONS: Despite an excellent tolerance and high efficacy-side effect ratio, this case report adds some evidence for an otoxicity of hydroxychloroquine.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Inserm
Université de Lille
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Research team(s) :

Glycation from inflammation to aging

Submission date :

2019-03-01T14:25:56Z