Hydroxychloroquine-induced hearing loss: ...
Document type :
Article dans une revue scientifique
PMID :
Permalink :
Title :
Hydroxychloroquine-induced hearing loss: First case of positive rechallenge and analysis of the French pharmacovigilance database.
Author(s) :
Chatelet, J-N [Auteur]
Auffret, M [Auteur]
Combret, S [Auteur]
Bondon-Guitton, E [Auteur]
Lambert, Marc [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Gautier, Sophie [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Auffret, M [Auteur]
Combret, S [Auteur]
Bondon-Guitton, E [Auteur]
Lambert, Marc [Auteur]

Lille Inflammation Research International Center - U 995 [LIRIC]
Gautier, Sophie [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Journal title :
La Revue de medecine interne
Abbreviated title :
Rev. Med. Interne
Volume number :
38
Pages :
340-343
Publication date :
2017-05-01
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
BACKGROUND: Several cases of hearing loss induced by hydroxychloroquine have been reported in the literature but the role of hydroxychloroquine still remains debated.
METHODS: We report the first case, to our knowledge, ...
Show more >BACKGROUND: Several cases of hearing loss induced by hydroxychloroquine have been reported in the literature but the role of hydroxychloroquine still remains debated. METHODS: We report the first case, to our knowledge, of hearing loss induced by hydroxychloroquine with a positive re challenge in a woman treated for systemic lupus. An analysis of the French pharmacovigilance database allowed to identify 23 additional cases of hearing loss in patients treated with hydroxychloroquine and, among them, 8 had systemic lupus. CONCLUSIONS: Despite an excellent tolerance and high efficacy-side effect ratio, this case report adds some evidence for an otoxicity of hydroxychloroquine.Show less >
Show more >BACKGROUND: Several cases of hearing loss induced by hydroxychloroquine have been reported in the literature but the role of hydroxychloroquine still remains debated. METHODS: We report the first case, to our knowledge, of hearing loss induced by hydroxychloroquine with a positive re challenge in a woman treated for systemic lupus. An analysis of the French pharmacovigilance database allowed to identify 23 additional cases of hearing loss in patients treated with hydroxychloroquine and, among them, 8 had systemic lupus. CONCLUSIONS: Despite an excellent tolerance and high efficacy-side effect ratio, this case report adds some evidence for an otoxicity of hydroxychloroquine.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Inserm
Université de Lille
CHU Lille
Université de Lille
CHU Lille
Research team(s) :
Glycation from inflammation to aging
Submission date :
2019-03-01T14:25:56Z
2021-06-09T07:11:50Z
2021-06-09T07:11:50Z