Title :

Transgenic Mouse Reporter to Study Muc5b In Vivo.

Author(s) :

Desseyn, Jean-Luc [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Portal, Celine [Auteur]
gottrand, Fréderic [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Lille Inflammation Research International Center (LIRIC) - U995
Gouyer, Valérie [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]

Journal title :

Annals of the American Thoracic Society

Abbreviated title :

Ann Am Thorac Soc

Volume number :

15

Pages :

S149-S153

Publisher :

ATS Journal

Publication date :

2018-11-01

ISSN :

2329-6933

Keyword(s) :

Muc5b-green fluorescent protein
green fluorescent protein live imaging
interleukin-13
mucins
mucus

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Dysregulation of gel-forming mucins is associated with many airway diseases. Better knowledge of the pathophysiological mechanisms linking mucins and respiratory diseases will advance the understanding of their pathogenesis ...
Show more >Dysregulation of gel-forming mucins is associated with many airway diseases. Better knowledge of the pathophysiological mechanisms linking mucins and respiratory diseases will advance the understanding of their pathogenesis and should provide opportunities to develop new therapeutic compounds for treatment. MUC5B and MUC5AC are the two main gel-forming mucins in the respiratory tract. The organization in domains and the expression profile of mouse Muc5b are very similar to those in humans, which makes the mouse a relevant model for studies of the translational activities of human mucins. To assess the in vivo biological functions of Muc5b, a mouse reporter tagged in frame with the green fluorescent protein marker has been engineered by homologous recombination. The proof of concept that this reporter model may be informative for translational studies was confirmed by the finding that interleukin-13 administration in living mice upregulated Muc5b production.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Inserm
Université de Lille
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Research team(s) :

Nutritional modulation of inflammation and infection

Submission date :

2019-03-01T14:34:29Z
2022-06-29T07:23:14Z