Clinical features and outcome of patients ...
Type de document :
Article dans une revue scientifique
PMID :
URL permanente :
Titre :
Clinical features and outcome of patients with acute respiratory failure revealing anti-synthetase or anti-MDA-5 dermato-pulmonary syndrome: a French multicenter retrospective study.
Auteur(s) :
Vuillard, Constance [Auteur]
Pineton De Chambrun, Marc [Auteur]
De Prost, Nicolas [Auteur]
Guerin, Claude [Auteur]
Schmidt, Matthieu [Auteur]
Dargent, Auguste [Auteur]
Quenot, Jean-Pierre [Auteur]
Preau, Sebastien [Auteur]
Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
Lille Inflammation Research International Center (LIRIC) - U995
Ledoux, Geoffrey [Auteur]
Neuville, Mathilde [Auteur]
Voiriot, Guillaume [Auteur]
Fartoukh, Muriel [Auteur]
Coudroy, Remi [Auteur]
Dumas, Guillaume [Auteur]
Maury, Eric [Auteur]
Terzi, Nicolas [Auteur]
Tandjaoui-Lambiotte, Yacine [Auteur]
Schneider, Francis [Auteur]
Grall, Maximilien [Auteur]
Guerot, Emmanuel [Auteur]
Larcher, Romaric [Auteur]
Ricome, Sylvie [Auteur]
Le Mao, Raphael [Auteur]
Colin, Gwenhael [Auteur]
Guitton, Christophe [Auteur]
Zafrani, Lara [Auteur]
Morawiec, Elise [Auteur]
Dubert, Marie [Auteur]
Pajot, Olivier [Auteur]
Mentec, Herve [Auteur]
Plantefeve, Gaetan [Auteur]
Contou, Damien [Auteur]
Pineton De Chambrun, Marc [Auteur]
De Prost, Nicolas [Auteur]
Guerin, Claude [Auteur]
Schmidt, Matthieu [Auteur]
Dargent, Auguste [Auteur]
Quenot, Jean-Pierre [Auteur]
Preau, Sebastien [Auteur]
Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
Lille Inflammation Research International Center (LIRIC) - U995
Ledoux, Geoffrey [Auteur]
Neuville, Mathilde [Auteur]
Voiriot, Guillaume [Auteur]
Fartoukh, Muriel [Auteur]
Coudroy, Remi [Auteur]
Dumas, Guillaume [Auteur]
Maury, Eric [Auteur]
Terzi, Nicolas [Auteur]
Tandjaoui-Lambiotte, Yacine [Auteur]
Schneider, Francis [Auteur]
Grall, Maximilien [Auteur]
Guerot, Emmanuel [Auteur]
Larcher, Romaric [Auteur]
Ricome, Sylvie [Auteur]
Le Mao, Raphael [Auteur]
Colin, Gwenhael [Auteur]
Guitton, Christophe [Auteur]
Zafrani, Lara [Auteur]
Morawiec, Elise [Auteur]
Dubert, Marie [Auteur]
Pajot, Olivier [Auteur]
Mentec, Herve [Auteur]
Plantefeve, Gaetan [Auteur]
Contou, Damien [Auteur]
Titre de la revue :
Annals of Intensive Care
Nom court de la revue :
Ann. Intensive Care
Numéro :
8
Pagination :
87
Date de publication :
2018-09-11
Mot(s)-clé(s) :
Diagnosis
Inflammatory myositis
Interstitial lung disease
ARDS
Acute respiratory failure
Inflammatory myositis
Interstitial lung disease
ARDS
Acute respiratory failure
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Background
Anti-synthetase (AS) and dermato-pulmonary associated with anti-MDA-5 antibodies (aMDA-5) syndromes are near one of the other autoimmune inflammatory myopathies potentially responsible for severe acute interstitial ...
Lire la suite >Background Anti-synthetase (AS) and dermato-pulmonary associated with anti-MDA-5 antibodies (aMDA-5) syndromes are near one of the other autoimmune inflammatory myopathies potentially responsible for severe acute interstitial lung disease. We undertook a 13-year retrospective multicenter study in 35 French ICUs in order to describe the clinical presentation and the outcome of patients admitted to the ICU for acute respiratory failure (ARF) revealing AS or aMDA-5 syndromes. Results From 2005 to 2017, 47 patients (23 males; median age 60 [1st–3rd quartiles 52–69] years, no comorbidity 85%) were admitted to the ICU for ARF revealing AS (n = 28, 60%) or aMDA-5 (n = 19, 40%) syndromes. Muscular, articular and cutaneous manifestations occurred in 11 patients (23%), 14 (30%) and 20 (43%) patients, respectively. Seventeen of them (36%) had no extra-pulmonary manifestations. C-reactive protein was increased (139 [40–208] mg/L), whereas procalcitonine was not (0.30 [0.12–0.56] ng/mL). Proportion of patients with creatine kinase ≥ 2N was 20% (n = 9/47). Forty-two patients (89%) had ARDS, which was severe in 86%, with a rate of 17% (n = 8/47) of extra-corporeal membrane oxygenation requirement. Proportion of patients who received corticosteroids, cyclophosphamide, rituximab, intravenous immunoglobulins and plasma exchange were 100%, 72%, 15%, 21% and 17%, respectively. ICU and hospital mortality rates were 45% (n = 21/47) and 51% (n = 24/47), respectively. Patients with aMDA-5 dermato-pulmonary syndrome had a higher hospital mortality than those with AS syndrome (n = 16/19, 84% vs. n = 8/28, 29%; p = 0.001). Conclusions Intensivists should consider inflammatory myopathies as a cause of ARF of unknown origin. Extra-pulmonary manifestations are commonly lacking. Mortality is high, especially in aMDA-5 dermato-pulmonary syndrome.Lire moins >
Lire la suite >Background Anti-synthetase (AS) and dermato-pulmonary associated with anti-MDA-5 antibodies (aMDA-5) syndromes are near one of the other autoimmune inflammatory myopathies potentially responsible for severe acute interstitial lung disease. We undertook a 13-year retrospective multicenter study in 35 French ICUs in order to describe the clinical presentation and the outcome of patients admitted to the ICU for acute respiratory failure (ARF) revealing AS or aMDA-5 syndromes. Results From 2005 to 2017, 47 patients (23 males; median age 60 [1st–3rd quartiles 52–69] years, no comorbidity 85%) were admitted to the ICU for ARF revealing AS (n = 28, 60%) or aMDA-5 (n = 19, 40%) syndromes. Muscular, articular and cutaneous manifestations occurred in 11 patients (23%), 14 (30%) and 20 (43%) patients, respectively. Seventeen of them (36%) had no extra-pulmonary manifestations. C-reactive protein was increased (139 [40–208] mg/L), whereas procalcitonine was not (0.30 [0.12–0.56] ng/mL). Proportion of patients with creatine kinase ≥ 2N was 20% (n = 9/47). Forty-two patients (89%) had ARDS, which was severe in 86%, with a rate of 17% (n = 8/47) of extra-corporeal membrane oxygenation requirement. Proportion of patients who received corticosteroids, cyclophosphamide, rituximab, intravenous immunoglobulins and plasma exchange were 100%, 72%, 15%, 21% and 17%, respectively. ICU and hospital mortality rates were 45% (n = 21/47) and 51% (n = 24/47), respectively. Patients with aMDA-5 dermato-pulmonary syndrome had a higher hospital mortality than those with AS syndrome (n = 16/19, 84% vs. n = 8/28, 29%; p = 0.001). Conclusions Intensivists should consider inflammatory myopathies as a cause of ARF of unknown origin. Extra-pulmonary manifestations are commonly lacking. Mortality is high, especially in aMDA-5 dermato-pulmonary syndrome.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
Inserm
Université de Lille
CHU Lille
Université de Lille
CHU Lille
Collections :
Équipe(s) de recherche :
Glycation from inflammation to aging
Date de dépôt :
2019-03-01T14:34:32Z
2024-03-06T14:11:13Z
2024-03-06T14:11:13Z
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