Title :

High-flow nasal cannula oxygen therapy alone or with non-invasive ventilation during the weaning period after extubation in ICU: the prospective randomised controlled HIGH-WEAN protocol.

Author(s) :

Thille Arnaud, W [Auteur]
Université de Poitiers = University of Poitiers [UP]
Muller, Gregoire [Auteur]
Gacouin, Arnaud [Auteur]
Coudroy, Remi [Auteur]
Université de Poitiers – UFR Santé [Faculté de Médecine et de Pharmacie] [UFR Santé [Poitiers]]
Demoule, Alexandre [Auteur]
Sorbonne Université [SU]
Sonneville, Romain [Auteur]
Université Paris Diderot - Paris 7 [UPD7]
Beloncle, Francois [Auteur]
Girault, Christophe [Auteur]
Université de Rouen Normandie [UNIROUEN]
Dangers, Laurence [Auteur]
Lautrette, Alexandre [Auteur]
Cabasson, Severin [Auteur]
Rouze, Anahita [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
Vivier, Emmanuel [Auteur]
Le Meur, Anthony [Auteur]
Ricard, Jean-Damien [Auteur]
Université Paris Diderot - Paris 7 [UPD7]
Razazi, Keyvan [Auteur]
Barberet, Guillaume [Auteur]
Lebert, Christine [Auteur]
Ehrmann, Stephan [Auteur]
Université de Tours [UT]
Picard, Walter [Auteur]
Bourenne, Jeremy [Auteur]
Aix Marseille Université [AMU]
Pradel, Gael [Auteur]
Bailly, Pierre [Auteur]
Terzi, Nicolas [Auteur]
Université Grenoble Alpes [UGA]
Buscot, Matthieu [Auteur]
Lacave, Guillaume [Auteur]
Danin, Pierre-Eric [Auteur]
Nanadoumgar, Hodanou [Auteur]
Gibelin, Aude [Auteur]
Zanre, Lassane [Auteur]
Deye, Nicolas [Auteur]
Ragot, Stephanie [Auteur]
Frat, Jean-Pierre [Auteur]

Journal title :

BMJ Open

Abbreviated title :

BMJ Open

Volume number :

8

Pages :

e023772

Publication date :

2018-09-05

Keyword(s) :

clinical trials
adult intensiv & critical care

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Introduction Recent practice guidelines suggest applying non-invasive ventilation (NIV) to prevent postextubation respiratory failure in patients at high risk of extubation failure in intensive care unit (ICU). However, ...
Show more >Introduction Recent practice guidelines suggest applying non-invasive ventilation (NIV) to prevent postextubation respiratory failure in patients at high risk of extubation failure in intensive care unit (ICU). However, such prophylactic NIV has been only a conditional recommendation given the low certainty of evidence. Likewise, high-flow nasal cannula (HFNC) oxygen therapy has been shown to reduce reintubation rates as compared with standard oxygen and to be as efficient as NIV in patients at high risk. Whereas HFNC may be considered as an optimal therapy during the postextubation period, HFNC associated with NIV could be an additional means of preventing postextubation respiratory failure. We are hypothesising that treatment associating NIV with HFNC between NIV sessions may be more effective than HFNC alone and may reduce the reintubation rate in patients at high risk. Methods and analysis This study is an investigator-initiated, multicentre randomised controlled trial comparing HFNC alone or with NIV sessions during the postextubation period in patients at high risk of extubation failure in the ICU. Six hundred patients will be randomised with a 1:1 ratio in two groups according to the strategy of oxygenation after extubation. The primary outcome is the reintubation rate within the 7 days following planned extubation. Secondary outcomes include the number of patients who meet the criteria for moderate/severe respiratory failure, ICU length of stay and mortality up to day 90.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Inserm
Université de Lille
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Research team(s) :

Fungal associated invasive and inflammatory diseases

Submission date :

2019-03-01T14:34:33Z
2024-03-04T09:39:58Z