Title :

Towards Precision Medicine in Sepsis: a position paper from the European Society of Clinical Microbiology and Infectious Diseases.

Author(s) :

Rello, Jordi [Auteur]
Van Engelen Tjitske S, R [Auteur]
Alp, Emine [Auteur]
Calandra, Thierry [Auteur]
Cattoir, Vincent [Auteur]
Kern Winfried, V [Auteur]
Netea Mihai, G [Auteur]
Nseir, Saad [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Opal Steven, M [Auteur]
Van De Veerdonk Frank, L [Auteur]
Wilcox Mark, H [Auteur]
Wiersinga W, Joost [Auteur]

Journal title :

Clinical Microbiology and Infection

Abbreviated title :

Clin. Microbiol. Infect.

Volume number :

24

Pages :

1264-1272

Publication date :

2018-12

ISSN :

1469-0691

Keyword(s) :

Host defence
Microbiome
Personalized medicine
Precision medicine
Rapid diagnostic test (RDT)
Theranostics
Treatment
Biomarkers
Low- and middle-income countries
Big data

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Background: Our current understanding of the pathophysiology and management of sepsis is associated with a lack of progress in clinical trials, which partly reflects insufficient appreciation of the heterogeneity of this ...
Show more >Background: Our current understanding of the pathophysiology and management of sepsis is associated with a lack of progress in clinical trials, which partly reflects insufficient appreciation of the heterogeneity of this syndrome. Consequently, more patient-specific approaches to treatment should be explored. Aims: To summarize the current evidence on precision medicine in sepsis, with an emphasis on translation from theory to clinical practice. A secondary objective is to develop a framework enclosing recommendations on management and priorities for further research. Sources: A global search strategy was performed in the MEDLINE database through the PubMed search engine (last search December 2017). No restrictions of study design, time, or language were imposed. Content: The focus of this Position Paper is on the interplay between therapies, pathogens, and the host. Regarding the pathogen, microbiologic diagnostic approaches (such as blood cultures (BCs) and rapid diagnostic tests (RDTs)) are discussed, as well as targeted antibiotic treatment. Other topics include the disruption of host immune system and the use of biomarkers in sepsis management, patient stratification, and future clinical trial design. Lastly, personalized antibiotic treatment and stewardship are addressed (Fig. 1). Implications: A road map provides recommendations and future perspectives. RDTs and identifying drug-response phenotypes are clear challenges. The next step will be the implementation of precision medicine to sepsis management, based on theranostic methodology. This highly individualized approach will be essential for the design of novel clinical trials and improvement of care pathways.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Inserm
Université de Lille
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Research team(s) :

Fungal associated invasive and inflammatory diseases

Submission date :

2019-03-01T14:35:39Z
2023-12-01T13:42:23Z