Impact of fish oils on the outcomes of a ...
Document type :
Article dans une revue scientifique
PMID :
Permalink :
Title :
Impact of fish oils on the outcomes of a mouse model of acute Pseudomonas aeruginosa pulmonary infection
Author(s) :
Caron, Emilie [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Desseyn, Jean-Luc [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Sergent, Luce [Auteur]
Bartke, Nana [Auteur]
Nutricia Research
Husson, Marie-Odile [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Duhamel, Alain [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
gottrand, frederic [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]

Lille Neurosciences & Cognition (LilNCog) - U 1172
Desseyn, Jean-Luc [Auteur]

Lille Inflammation Research International Center - U 995 [LIRIC]
Sergent, Luce [Auteur]
Bartke, Nana [Auteur]
Nutricia Research
Husson, Marie-Odile [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Duhamel, Alain [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
gottrand, frederic [Auteur]

Lille Inflammation Research International Center - U 995 [LIRIC]
Journal title :
The British journal of nutrition
Abbreviated title :
Br. J. Nutr.
Volume number :
113
Pages :
191-199
Publication date :
2015-01-28
ISSN :
0007-1145
Keyword(s) :
Pseudomonas aeruginosa infection
Inflammation
Alkylglycerols
n-3 Long-chain PUFA
Inflammation
Alkylglycerols
n-3 Long-chain PUFA
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Pseudomonas aeruginosa is an opportunistic Gram-negative bacterium that causes pneumonia in immunocompromised humans and severe pulmonary damage in patients with cystic fibrosis. Imbalanced fatty acid incorporation in ...
Show more >Pseudomonas aeruginosa is an opportunistic Gram-negative bacterium that causes pneumonia in immunocompromised humans and severe pulmonary damage in patients with cystic fibrosis. Imbalanced fatty acid incorporation in membranes, including increased arachidonic acid and decreased DHA concentrations, is known to play a critical role in chronic inflammation associated with bacterial infection. Other lipids, such as EPA and alkylglycerols, are also known to play a role in inflammation, particularly by stimulating the immune system, decreasing inflammation and inhibiting bacterial growth. In this context, the goal of the present study was to assess the effect of dietary DHA/EPA, in a 2:1 ratio, and alkylglycerols, as natural compounds extracted from oils of rays and chimeras, respectively, on the inflammatory reaction induced by P. aeruginosa pulmonary infection in mice. To this end, mice were fed with a control diet or isolipidic, isoenergetic diets prepared with oils enriched in DHA/EPA (2:1) or alkylglycerols for 5 weeks before the induction of acute P. aeruginosa lung infection by endotracheal instillation. In our model, DHA/EPA (2:1) significantly improved the survival of mice after infection, which was associated with the acceleration of bacterial clearance and the resolution of inflammation leading to the improvement of pulmonary injuries. By contrast, alkylglycerols did not affect the outcomes of P. aeruginosa infection. Our findings suggest that supplementation with ray oil enriched in DHA/EPA (2:1) can be considered as a preventive treatment for patients at risk for P. aeruginosa infectiShow less >
Show more >Pseudomonas aeruginosa is an opportunistic Gram-negative bacterium that causes pneumonia in immunocompromised humans and severe pulmonary damage in patients with cystic fibrosis. Imbalanced fatty acid incorporation in membranes, including increased arachidonic acid and decreased DHA concentrations, is known to play a critical role in chronic inflammation associated with bacterial infection. Other lipids, such as EPA and alkylglycerols, are also known to play a role in inflammation, particularly by stimulating the immune system, decreasing inflammation and inhibiting bacterial growth. In this context, the goal of the present study was to assess the effect of dietary DHA/EPA, in a 2:1 ratio, and alkylglycerols, as natural compounds extracted from oils of rays and chimeras, respectively, on the inflammatory reaction induced by P. aeruginosa pulmonary infection in mice. To this end, mice were fed with a control diet or isolipidic, isoenergetic diets prepared with oils enriched in DHA/EPA (2:1) or alkylglycerols for 5 weeks before the induction of acute P. aeruginosa lung infection by endotracheal instillation. In our model, DHA/EPA (2:1) significantly improved the survival of mice after infection, which was associated with the acceleration of bacterial clearance and the resolution of inflammation leading to the improvement of pulmonary injuries. By contrast, alkylglycerols did not affect the outcomes of P. aeruginosa infection. Our findings suggest that supplementation with ray oil enriched in DHA/EPA (2:1) can be considered as a preventive treatment for patients at risk for P. aeruginosa infectiShow less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Inserm
Université de Lille
CHU Lille
Université de Lille
CHU Lille
Collections :
Research team(s) :
Nutritional modulation of inflammation and infection
Submission date :
2019-03-01T14:47:02Z
2022-09-28T08:11:55Z
2022-09-28T08:11:55Z