Title :

Immunogenicity and Safety of Influenza Vaccine in Inflammatory Bowel Disease Patients Treated or not with Immunomodulators and/or Biologics: A Two-year Prospective Study

Author(s) :

Launay, Odile [Auteur]
Abitbol, Vered [Auteur]
Krivine, Anne [Auteur]
Ben Slama, Lilia [Auteur]
Bourreille, Arnaud [Auteur]
Dupas, Jean-Louis [Auteur]
Hebuterne, Xavier [Auteur]
Savoye, Guillaume [Auteur]
Deplanque, Dominique [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Bouhnik, Yoram [Auteur]
Pelletier, Anne-Laure [Auteur]
Galtier, Florence [Auteur]
Laharie, David [Auteur]
Nachury, Maria [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Lille Inflammation Research International Center - U 995 [LIRIC]
Zerbib, Frank [Auteur]
Allez, Matthieu [Auteur]
Bommelaer, Gilles [Auteur]
Duclos, Bernard [Auteur]
Lucht, Frederic [Auteur]
Gougeon, Marie-Lise [Auteur]
Tartour, Eric [Auteur]
Rozenberg, Flore [Auteur]
Hanslik, Thomas [Auteur]
Beaugerie, Laurent [Auteur]
Carrat, Fabrice [Auteur]

Journal title :

Journal of Crohn's & colitis

Abbreviated title :

J. Crohns Colitis

Volume number :

9

Pages :

1096-1107

Publication date :

2015-12-01

ISSN :

1873-9946

Keyword(s) :

anti-TNF
safety
Vaccine immune response

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

OBJECTIVE: Data on the efficacy and safety of seasonal influenza vaccines in patients with inflammatory bowel disease (IBD) remain scarce. The aim of the study was to evaluate the impact of immunosuppressive (IS) therapeutics ...
Show more >OBJECTIVE: Data on the efficacy and safety of seasonal influenza vaccines in patients with inflammatory bowel disease (IBD) remain scarce. The aim of the study was to evaluate the impact of immunosuppressive (IS) therapeutics on serological response to 2-year influenza vaccination in IBD adults. METHODS: A multicentre prospective study performed in 255 IBD adults (18-64 years) receiving the trivalent influenza vaccine in the years 2009-2010 and 2010-2011. Haemagglutination inhibition (HI) titres were assessed before and 3 weeks and 6 months after vaccination. RESULTS: At inclusion, 31 patients were receiving no IS treatment (Group A), 77 were receiving IS treatment without anti-TNF (Group B) and 117 were receiving anti-tumour necrosis factor (TNF) treatment with or without IS treatment (Group C). Three weeks after the first vaccination, rates of seroprotection were 77, 75 and 66% for strain A/H1N12007 (p = 0.35), 77, 68 and 52% for strain A/H3N2 (p = 0.014) and 97, 96 and 95% for strain B (p = 0.99) in Groups A, B and C, respectively. Seroconversion rates for A/H1N12007 (67, 64 and 54%; p = 0.28), A/H3N2 (63, 50 and 41%; p = 0.074) and strain B (63, 76 and 60%; p = 0.078) were not significantly different among treatment groups. At 6 months after vaccination, seroprotection rates were lower in Group C compared with Groups A and B. Comparable results were observed for the second year of vaccination. No impact on Harvey-Bradshaw and Mayo scores was detected. CONCLUSIONS: Influenza vaccine yielded high seroprotection rates in IBD patients. Persistence of seroprotection was lower in patients with anti-TNF treatment. ClinicalTrials.gov, number NCT01022749.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Inserm
Université de Lille
CHU Lille
CNRS

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Research team(s) :

Inflammatory digestive disease : pathophysiology and therapeutic targets developement

Submission date :

2019-03-01T15:14:08Z