Postoperative Complications in Pediatric ...
Document type :
Article dans une revue scientifique
PMID :
Permalink :
Title :
Postoperative Complications in Pediatric Inflammatory Bowel Disease: A Population-based Study
Author(s) :
Penninck, Eugenie [Auteur]
Hôpital Claude Huriez [Lille]
Fumery, Mathurin [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Armengol-Debeir, Laura [Auteur]
Service d'Hépato-Gastroentérologie [CHU Rouen]
Sarter, Helene [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Savoye, Guillaume [Auteur]
Service d'Hépato-Gastroentérologie [CHU Rouen]
Turck, Dominique [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Pineton De Chambrun, Guillaume [Auteur]
Hôpital Claude Huriez [Lille]
Vasseur, Francis [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Dupas, Jean-Louis [Auteur]
Service d'Hépato-Gastroentérologie [CHU Rouen]
Lerebours, Eric [Auteur]
Service d'Hépato-Gastroentérologie [CHU Rouen]
Colombel, Jean-Frederic [Auteur]
Hôpital Claude Huriez [Lille]
Icahn School of Medicine at Mount Sinai [New York] [MSSM]
Peyrin-Biroulet, Laurent [Auteur]
Service de Chirurgie Digestive Hépatobiliaire et Endocrine [CHRU Nancy]
Centre Hospitalier Universitaire de Nancy [CHU Nancy]
Gower, Corinne [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Hôpital Claude Huriez [Lille]
Fumery, Mathurin [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Armengol-Debeir, Laura [Auteur]
Service d'Hépato-Gastroentérologie [CHU Rouen]
Sarter, Helene [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Savoye, Guillaume [Auteur]
Service d'Hépato-Gastroentérologie [CHU Rouen]
Turck, Dominique [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Pineton De Chambrun, Guillaume [Auteur]
Hôpital Claude Huriez [Lille]
Vasseur, Francis [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Dupas, Jean-Louis [Auteur]
Service d'Hépato-Gastroentérologie [CHU Rouen]
Lerebours, Eric [Auteur]
Service d'Hépato-Gastroentérologie [CHU Rouen]
Colombel, Jean-Frederic [Auteur]
Hôpital Claude Huriez [Lille]
Icahn School of Medicine at Mount Sinai [New York] [MSSM]
Peyrin-Biroulet, Laurent [Auteur]
Service de Chirurgie Digestive Hépatobiliaire et Endocrine [CHRU Nancy]
Centre Hospitalier Universitaire de Nancy [CHU Nancy]
Gower, Corinne [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Journal title :
Inflammatory bowel diseases
Abbreviated title :
Inflamm. Bowel Dis.
Volume number :
22
Pages :
127-133
Publisher :
Oxford Academic
Publication date :
2016-01-01
ISSN :
1078-0998
Keyword(s) :
pediatric
postoperative complications
inflammatory bowel disease
postoperative complications
inflammatory bowel disease
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Methods
Using the pediatric population-based EPIMAD Cohort (1988–2004), among 692 incident inflammatory bowel disease cases, 128 patients with Crohn's disease (CD) and 25 with ulcerative colitis (UC) (22%) had undergone ...
Show more >Methods Using the pediatric population-based EPIMAD Cohort (1988–2004), among 692 incident inflammatory bowel disease cases, 128 patients with Crohn's disease (CD) and 25 with ulcerative colitis (UC) (22%) had undergone at least 1 major abdominal surgery at a median age of 16 years [interquartile range, Q1–Q3 = 14–17]. Factors associated with POC were assessed using Cox models. Results After a median postoperative follow-up of 8 years (3–12), 76 (49.7%) patients had experienced at least 1 POC with a total of 113 complications. The frequency of severe POC (grade >2) was similar in CD and UC (28% of all complications versus 27%, P = 0.95). A total of 64 early POCs (within 30 d of surgery) were observed in 47 patients (31%), with 33 being infectious and 31 noninfectious, higher in UC than in CD (25% of patients with CD versus 60% of patients with UC, P < 0.001). Forty-nine late POCs (≥30 d) were observed in 37 patients (24%). The occurrence of late POC was similar in UC and CD. The cumulative probability of POC was 31% (95% confidence interval, 24–39) at 1 month, 46% (38–54) at 1 year, and 48% (41–57) at 5 years. Multivariate analysis found that the UC type was the only factor associated with early POC (hazard ratio = 2.9; 95% confidence interval, 1.6–5.4). Conclusions One-half of the children with inflammatory bowel disease had experienced at least 1 POC. Only UC relative to CD was significantly associated with an increased risk of early POC.Show less >
Show more >Methods Using the pediatric population-based EPIMAD Cohort (1988–2004), among 692 incident inflammatory bowel disease cases, 128 patients with Crohn's disease (CD) and 25 with ulcerative colitis (UC) (22%) had undergone at least 1 major abdominal surgery at a median age of 16 years [interquartile range, Q1–Q3 = 14–17]. Factors associated with POC were assessed using Cox models. Results After a median postoperative follow-up of 8 years (3–12), 76 (49.7%) patients had experienced at least 1 POC with a total of 113 complications. The frequency of severe POC (grade >2) was similar in CD and UC (28% of all complications versus 27%, P = 0.95). A total of 64 early POCs (within 30 d of surgery) were observed in 47 patients (31%), with 33 being infectious and 31 noninfectious, higher in UC than in CD (25% of patients with CD versus 60% of patients with UC, P < 0.001). Forty-nine late POCs (≥30 d) were observed in 37 patients (24%). The occurrence of late POC was similar in UC and CD. The cumulative probability of POC was 31% (95% confidence interval, 24–39) at 1 month, 46% (38–54) at 1 year, and 48% (41–57) at 5 years. Multivariate analysis found that the UC type was the only factor associated with early POC (hazard ratio = 2.9; 95% confidence interval, 1.6–5.4). Conclusions One-half of the children with inflammatory bowel disease had experienced at least 1 POC. Only UC relative to CD was significantly associated with an increased risk of early POC.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Inserm
Université de Lille
CHU Lille
Université de Lille
CHU Lille
Collections :
Research team(s) :
Inflammatory digestive disease : pathophysiology and therapeutic targets developement
Nutritional modulation of inflammation and infection
IBD and environnemental factors : epidemiology and functional analyses
Nutritional modulation of inflammation and infection
IBD and environnemental factors : epidemiology and functional analyses
Submission date :
2019-03-01T15:14:09Z
2022-09-21T09:06:53Z
2022-09-21T09:06:53Z