Coxsackievirus B4 Can Infect Human Peripheral Blood- Derived Macrophages

Alidjinou, Enagnon-Kazali; Sane, Famara; Trauet, Jacques; Copin, Marie-Christine; Hober, Didier

Type de document :

Article dans une revue scientifique

DOI :

10.3390/v7112924

PMID :

26610550

URL permanente :

http://hdl.handle.net/20.500.12210/5250

Titre :

Coxsackievirus B4 Can Infect Human Peripheral Blood- Derived Macrophages

Auteur(s) :

Alidjinou, Enagnon-Kazali [Auteur]

Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
Sane, Famara [Auteur]

Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
Trauet, Jacques [Auteur]

Lille Inflammation Research International Center - U 995 [LIRIC]
Copin, Marie-Christine [Auteur]

Mécanismes de la Tumorigénèse et Thérapies Ciblées - UMR 8161 [M3T]
Hober, Didier [Auteur]

Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]

Titre de la revue :

Viruses

Nom court de la revue :

Viruses-Basel

Numéro :

Pagination :

6067-6079

Date de publication :

2015-11-24

ISSN :

1999-4915

Mot(s)-clé(s) :

persistence
inflammation
GM-CSF
monocyte-derived macrophages
M-CSF
infection
coxsackievirus B

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Beyond acute infections, group B coxsackieviruses (CVB) are also reported to play a role in the development of chronic diseases, like type 1 diabetes. The viral pathogenesis mainly relies on the interplay between the viruses ...
Lire la suite >Beyond acute infections, group B coxsackieviruses (CVB) are also reported to play a role in the development of chronic diseases, like type 1 diabetes. The viral pathogenesis mainly relies on the interplay between the viruses and innate immune response in genetically-susceptible individuals. We investigated the interaction between CVB4 and macrophages considered as major players in immune response. Monocyte-derived macrophages (MDM) generated with either M-CSF or GM-CSF were inoculated with CVB4, and infection, inflammation, viral replication and persistence were assessed. M-CSF-induced MDM, but not GM-CSF-induced MDM, can be infected by CVB4. In addition, enhancing serum was not needed to infect MDM in contrast with parental monocytes. The expression of viral receptor (CAR) mRNA was similar in both M-CSF and GM-CSF MDM. CVB4 induced high levels of pro-inflammatory cytokines (IL-6 and TNFα) in both MDM populations. CVB4 effectively replicated and persisted in M-CSF MDM, but IFNα was produced in the early phase of infection only. Our results demonstrate that CVB4 can replicate and persist in MDM. Further investigations are required to determine whether the interaction between the virus and MDM plays a role in the pathogenesis of CVB-induced chronic diseases.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Inserm
Université de Lille
CHU Lille
CNRS

Collections :

Équipe(s) de recherche :

Immunity, inflammation and fibrsis in auto and allo-reactivity

Date de dépôt :

2019-03-01T15:15:48Z
2022-11-16T09:53:40Z

Fichiers

viruses-07-02924.pdf
Version éditeur
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Ce document est diffusé sous licence Attribution 3.0 United States

Numéro de version	Lien	Date de modification
2	20.500.12210/5250*	2022-11-16T09:46:36Z
1	20.500.12210/5250.1	2019-03-01T15:15:48Z

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