Title :

Candida albicans beta-1,2 mannosyl transferase Bmt3: Preparation and evaluation of a beta (1,2), alpha (1,2)-tetramannosyl fluorescent substrate

Author(s) :

Cattiaux, Laurent [Auteur]
Laboratoire des biomolécules [LBM UMR 7203]
Mee, Anais [Auteur]
Laboratoire des biomolécules [LBM UMR 7203]
Pourcelot, Marilyne [Auteur]
Laboratoire des biomolécules [LBM UMR 7203]
Sfihi-Loualia, Ghenima [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle [UGSF]
Hurtaux, Thomas [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Unité de Glycobiologie Structurale et Fonctionnelle [UGSF]
Maes, Emmanuel [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF]
Fradin, Chantal [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Sendid, Boualem [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Poulain, Daniel [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Fabre, Emeline [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle [UGSF]
Delplace, Florence [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF]
Guerardel, Yann [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF]
Mallet, Jean-Maurice [Auteur]
Laboratoire des biomolécules [LBM UMR 7203]

Journal title :

Bioorganic & medicinal chemistry

Abbreviated title :

Bioorg. Med. Chem.

Volume number :

24

Pages :

1362-1368

Publication date :

2016-03-15

ISSN :

0968-0896

Keyword(s) :

Lauryl glycoside
Glycosylation

English keyword(s) :

Glycosylation
Lauryl glycoside
Beta mannosides
Mannosyl transferases
Fluorescent substrate
Mantyl

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

We describe for the first time the chemical synthesis of a tetramannoside, containing both α (1 → 2) and β (1 → 2) linkages. Dodecylthio (lauryl) glycosides were prepared from odorless dodecyl thiol and used as donors for ...
Show more >We describe for the first time the chemical synthesis of a tetramannoside, containing both α (1 → 2) and β (1 → 2) linkages. Dodecylthio (lauryl) glycosides were prepared from odorless dodecyl thiol and used as donors for the glycosylation steps. This tetramannoside, was coupled to a mantyl group, and revealed to be a perfect substrate of β-mannosyltransferase Bmt3, confirming the proposed specificity and allowing the preparation of a pentamannoside sequence (β Man (1,2) β Man (1,2) α Man (1,2) α Man (1,2) α Man) usable as a novel substrate for further elongation studies.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Inserm
Université de Lille
CHU Lille
CNRS

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
• Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576

Research team(s) :

Fungal associated invasive and inflammatory diseases
IBD and environnemental factors : epidemiology and functional analyses

Submission date :

2019-03-01T15:16:01Z
2021-03-19T07:47:16Z