Title :

Incidence, Clinical Presentation, and Associated Factors of Microscopic Colitis in Northern France: A Population-Based Study

Author(s) :

Fumery, Mathurin [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Kohut, Mathieu [Auteur]
Clinique Sainte Isabelle [Abbeville, France]
Gower, Corinne [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Duhamel, Alain [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Brazier, Franck [Auteur]
Service d'Hépato Gastroenterologie [CHU Amiens-Picardie]
Thelu, Francoise [Auteur]
Nagorniewicz, Francis [Auteur]
Lamarche, Francois [Auteur]
Nguyen-Khac, Eric [Auteur]
Service d'Hépato Gastroenterologie [CHU Amiens-Picardie]
Sabbagh, Charles [Auteur]
Chirurgie digestive [CHU Amiens]
Université de Picardie Jules Verne [UPJV]
Loreau, Julien [Auteur]
Service d'Hépato Gastroenterologie [CHU Amiens-Picardie]
Université de Picardie Jules Verne [UPJV]
Colombel, Jean-Frederic [Auteur]
Icahn School of Medicine at Mount Sinai [New York] [MSSM]
Savoye, Guillaume [Auteur]
Service d'Hépato-Gastroentérologie [CHU Rouen]
Chatelain, Denis [Auteur]
Dupas, Jean-Louis [Auteur]
Service d'Hépato Gastroenterologie [CHU Amiens-Picardie]

Journal title :

Digestive diseases and sciences

Abbreviated title :

Dig. Dis. Sci.

Volume number :

62

Pages :

1571-1579

Publisher :

Springer Link

Publication date :

2017-06-01

ISSN :

0163-2116

Keyword(s) :

Incidence
Lymphocytic colitis
Collagenous colitis
Population based
Microscopic colitis

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Objective To date, there are no epidemiological data on microscopic colitis (MC) in France. The aim of this study was to determine the incidence of MC in the Somme department in Northern France, to evaluate clinical ...
Show more >Objective To date, there are no epidemiological data on microscopic colitis (MC) in France. The aim of this study was to determine the incidence of MC in the Somme department in Northern France, to evaluate clinical characteristics, and to search for risk factors for both collagenous colitis (CC) and lymphocytic colitis (LC). Design Between January 1, 2005, and December 31, 2007, four pathology units in the Somme department recorded all new cases of MC diagnosed in patients living in the area. Colonic biopsies were reviewed by 4 pathologists together. For each incident case, demographic, clinical, endoscopic, and biological data were collected according to methodology of the EPIMAD registry. Results One hundred and thirty cases of MC, including 87 CC and 43 LC, were recorded during the three-year study. The mean annual incidence for MC was 7.9/105 inhabitants, 5.3/105 inhabitants for CC, and 2.6/105 inhabitants for LC. Annual standardized incidence of Crohn’s disease and ulcerative colitis in the EPIMAD registry during the same period (2005–2007) were 7.4/105 and 4.9/105, respectively. Median age at diagnosis was 63 years for MC, 70 for CC, and 48 for LC. The female-to-male gender ratio was 3.5 for MC, 4.1 for CC, and 2.6 for LC. Median time to diagnosis was 8 weeks. Chronic diarrhea and abdominal pain were, respectively, present in 93 and 47 % of the cases. An autoimmune disease was associated in 28 % of MC cases. At diagnosis, proton pump inhibitor treatment was more often reported in CC than in LC (46 vs 16 %; p = 0.003). Budesonide was effective on diarrhea in 77 % of patients, and thirteen percent of patients became steroid dependent. Conclusion This population-based study shows that the incidence of MC in France is high and similar to Crohn’s disease incidence and confirms that this condition is associated with female gender, autoimmune diseases, and medications.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Inserm
Université de Lille
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Research team(s) :

Inflammatory digestive disease : pathophysiology and therapeutic targets developement
IBD and environnemental factors : epidemiology and functional analyses

Submission date :

2019-03-01T15:16:43Z
2022-09-21T09:41:59Z