Gut microbiota limits heavy metals burden ...
Document type :
Article dans une revue scientifique: Article original
PMID :
Title :
Gut microbiota limits heavy metals burden caused by chronic oral exposure
Author(s) :
Breton, Jérôme [Auteur]
Lactic Acid Bacteria & Mucosal Immunity - CIIL
Daniel, Catherine [Auteur]
Lactic Acid Bacteria & Mucosal Immunity - CIIL
Dewulf, Joëlle [Auteur]
Lactic Acid Bacteria & Mucosal Immunity - CIIL
Pothion, Stéphanie [Auteur]
Transgenèse et archivage d'animaux modèles [TAAM]
Froux, Nathalie [Auteur]
Transgenèse et archivage d'animaux modèles [TAAM]
Sauty, Mathieu [Auteur]
Institut Pasteur de Lille
Thomas, Patrick [Auteur]
Institut Pasteur de Lille
Pot, Bruno [Auteur]
Lactic Acid Bacteria & Mucosal Immunity - CIIL
Foligné, Benoît [Auteur correspondant]
Lactic Acid Bacteria & Mucosal Immunity - CIIL
Lactic Acid Bacteria & Mucosal Immunity - CIIL
Daniel, Catherine [Auteur]
Lactic Acid Bacteria & Mucosal Immunity - CIIL
Dewulf, Joëlle [Auteur]
Lactic Acid Bacteria & Mucosal Immunity - CIIL
Pothion, Stéphanie [Auteur]
Transgenèse et archivage d'animaux modèles [TAAM]
Froux, Nathalie [Auteur]
Transgenèse et archivage d'animaux modèles [TAAM]
Sauty, Mathieu [Auteur]
Institut Pasteur de Lille
Thomas, Patrick [Auteur]
Institut Pasteur de Lille
Pot, Bruno [Auteur]
Lactic Acid Bacteria & Mucosal Immunity - CIIL
Foligné, Benoît [Auteur correspondant]
Lactic Acid Bacteria & Mucosal Immunity - CIIL
Journal title :
Toxicology Letters
Pages :
132-138
Publisher :
Elsevier
Publication date :
2013-10-24
ISSN :
0378-4274
English keyword(s) :
Cadmium
Lead
Gut microbiota
Germ-free mice
Bioavailability
Gene expression
Lead
Gut microbiota
Germ-free mice
Bioavailability
Gene expression
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Environmental exposure to pollutants such as heavy metal(s) is responsible for various altered physiological functions which are detrimental for health. The gut microbiota is critical for intestinal homeostasis but its ...
Show more >Environmental exposure to pollutants such as heavy metal(s) is responsible for various altered physiological functions which are detrimental for health. The gut microbiota is critical for intestinal homeostasis but its role on xenobiotic handling is not fully understood, especially when continuous sub-chronic exposure is addressed. We first confirmed the essential role of the intestinal microbiome to limit heavy metal body burden by using germ-free mice following 6-weeks oral exposure. Significant increases of cadmium and lead absorption and dissemination in blood and target organs were measured in germ-free mice when compared with conventional specific pathogen free (SPF) mice. Besides the “barrier” function of the luminal microbiota, this may involve specific host-genes such as metallothioneins, which are differentially expressed in the gastrointestinal tract of each group of mice. Considering genes relevant for divalent metal transporters and oxidative pathways, significant differences in basal gene expression were measured between control and germ-free mice. Moreover, the magnitude of induction of these genes upon stimulation by heavy metals varied greatly depending on the dose and type of metal as well as the microbial status of the animal. Collectively, these data illustrate the complex host-microbes interplay occurring with environmental pollutants inside the gut.Show less >
Show more >Environmental exposure to pollutants such as heavy metal(s) is responsible for various altered physiological functions which are detrimental for health. The gut microbiota is critical for intestinal homeostasis but its role on xenobiotic handling is not fully understood, especially when continuous sub-chronic exposure is addressed. We first confirmed the essential role of the intestinal microbiome to limit heavy metal body burden by using germ-free mice following 6-weeks oral exposure. Significant increases of cadmium and lead absorption and dissemination in blood and target organs were measured in germ-free mice when compared with conventional specific pathogen free (SPF) mice. Besides the “barrier” function of the luminal microbiota, this may involve specific host-genes such as metallothioneins, which are differentially expressed in the gastrointestinal tract of each group of mice. Considering genes relevant for divalent metal transporters and oxidative pathways, significant differences in basal gene expression were measured between control and germ-free mice. Moreover, the magnitude of induction of these genes upon stimulation by heavy metals varied greatly depending on the dose and type of metal as well as the microbial status of the animal. Collectively, these data illustrate the complex host-microbes interplay occurring with environmental pollutants inside the gut.Show less >
Language :
Anglais
Peer reviewed article :
Oui
Audience :
Internationale
Popular science :
Non
Source :
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