Outcome and prognostic factors of patients ...
Document type :
Article dans une revue scientifique
PMID :
Permalink :
Title :
Outcome and prognostic factors of patients with right-sided infective endocarditis requiring intensive care unit admission
Author(s) :
Georges, Hugues [Auteur]
Centre Hospitalier Tourcoing
Leroy, Olivier [Auteur]
Centre Hospitalier Tourcoing
Airapetian, Norair [Auteur]
CHU Amiens-Picardie
Lamblin, Nicolas [Auteur]
Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 [RID-AGE]
Zogheib, Elie [Auteur]
CHU Amiens-Picardie
Devos, Patrick [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Preau, Sebastien [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
Lille Inflammation Research International Center - U 995 [LIRIC]
Centre Hospitalier Tourcoing
Leroy, Olivier [Auteur]
Centre Hospitalier Tourcoing
Airapetian, Norair [Auteur]
CHU Amiens-Picardie
Lamblin, Nicolas [Auteur]

Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 [RID-AGE]
Zogheib, Elie [Auteur]
CHU Amiens-Picardie
Devos, Patrick [Auteur]

METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Preau, Sebastien [Auteur]

Lille Inflammation Research International Center (LIRIC) - U995
Lille Inflammation Research International Center - U 995 [LIRIC]
Journal title :
BMC infectious diseases
Abbreviated title :
BMC Infect. Dis.
Volume number :
18
Publication date :
2018-02-21
ISSN :
1471-2334
Keyword(s) :
Mesh:Survival Analysis
Mesh:Adult
Mesh:Endocarditis/mortality
Mesh:Aminoglycosides/therapeutic use
Mesh:Humans
Mesh:Bacteriocins/isolation & purification
Mesh:Endocarditis/drug therapy
Mesh:Substance Abuse
Mesh:Intravenous/complications
Mesh:Endocarditis/etiology
Mesh:Prognosis
Mesh:Female
Mesh:Vancomycin/therapeutic use
Mesh:Intensive Care Units
Mesh:Hospitalization
Mesh:Catheter-Related Infections/complications
Mesh:Endocarditis/diagnosis*
Mesh:Anti-Bacterial Agents/therapeutic use
Mesh:Middle Aged
Mesh:Logistic Models
Mesh:Retrospective Studies
Mesh:Male
Mesh:Treatment Outcome
Mesh:Aged
Intensive care unit
Prognostic factors
Right-sided infective endocarditis
Mesh:Adult
Mesh:Endocarditis/mortality
Mesh:Aminoglycosides/therapeutic use
Mesh:Humans
Mesh:Bacteriocins/isolation & purification
Mesh:Endocarditis/drug therapy
Mesh:Substance Abuse
Mesh:Intravenous/complications
Mesh:Endocarditis/etiology
Mesh:Prognosis
Mesh:Female
Mesh:Vancomycin/therapeutic use
Mesh:Intensive Care Units
Mesh:Hospitalization
Mesh:Catheter-Related Infections/complications
Mesh:Endocarditis/diagnosis*
Mesh:Anti-Bacterial Agents/therapeutic use
Mesh:Middle Aged
Mesh:Logistic Models
Mesh:Retrospective Studies
Mesh:Male
Mesh:Treatment Outcome
Mesh:Aged
Intensive care unit
Prognostic factors
Right-sided infective endocarditis
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Background
Right-sided infective endocarditis (RSIE) is an uncommon diagnosis accounting for less than 10% of cases of infective endocarditis. Optimal management for severely ill patients with RSIE remains challenging ...
Show more >Background Right-sided infective endocarditis (RSIE) is an uncommon diagnosis accounting for less than 10% of cases of infective endocarditis. Optimal management for severely ill patients with RSIE remains challenging because few studies reported on management and outcome. The goal of our study was to determine outcome and associated prognostic factors in a population of ICU patients with a diagnosis of definite, active and severe RSIE. Methods We performed a retrospective study in 10 French ICUs between January 2002 and December 2012. Main outcome was mortality at 30 days after ICU admission. Significant variables associated with 30-days mortality in the bivariate analysis were included in a logistic regression analysis. Results A total of 37 patients were studied. Mean age was 47.9 ± 18.4 years. Mean SAPS II, SOFA score and Charlson comorbidity index were 32.4 ± 17.4, 6.3 ± 4.4 and 3.1 ± 3.4, respectively. Causative pathogens, identified in 34 patients, were mainly staphylococci (n = 29). The source of endocarditis was a catheter related infection in 10 patients, intravenous drug abuse in 8 patients, cutaneous in 7 patients, urinary tract related in one patient and has an unknown origin in 7 patients. Vegetation size was higher than 20 mm for 14 patients. Valve tricuspid regurgitation was classified as severe in 11 patients. All patients received initial appropriate antimicrobial therapy. Aminoglycosides were delivered in combination with β-lactam antibiotics or vancomycin in 22 patients. Surgical procedure was performed in 14 patients. Eight patients (21.6%) died within 30 days following ICU admission. One independent prognostic factor was identified: use of aminoglycosides was associated with improved outcome (OR = 0.1; 95%CI = 0.0017–0.650; p = 0.007). Conclusion Mortality of patients with RSIE needing ICU admission is high. Aminoglycosides used in combination with β-lactam or vancomycin could reduce 30 days mortality.Show less >
Show more >Background Right-sided infective endocarditis (RSIE) is an uncommon diagnosis accounting for less than 10% of cases of infective endocarditis. Optimal management for severely ill patients with RSIE remains challenging because few studies reported on management and outcome. The goal of our study was to determine outcome and associated prognostic factors in a population of ICU patients with a diagnosis of definite, active and severe RSIE. Methods We performed a retrospective study in 10 French ICUs between January 2002 and December 2012. Main outcome was mortality at 30 days after ICU admission. Significant variables associated with 30-days mortality in the bivariate analysis were included in a logistic regression analysis. Results A total of 37 patients were studied. Mean age was 47.9 ± 18.4 years. Mean SAPS II, SOFA score and Charlson comorbidity index were 32.4 ± 17.4, 6.3 ± 4.4 and 3.1 ± 3.4, respectively. Causative pathogens, identified in 34 patients, were mainly staphylococci (n = 29). The source of endocarditis was a catheter related infection in 10 patients, intravenous drug abuse in 8 patients, cutaneous in 7 patients, urinary tract related in one patient and has an unknown origin in 7 patients. Vegetation size was higher than 20 mm for 14 patients. Valve tricuspid regurgitation was classified as severe in 11 patients. All patients received initial appropriate antimicrobial therapy. Aminoglycosides were delivered in combination with β-lactam antibiotics or vancomycin in 22 patients. Surgical procedure was performed in 14 patients. Eight patients (21.6%) died within 30 days following ICU admission. One independent prognostic factor was identified: use of aminoglycosides was associated with improved outcome (OR = 0.1; 95%CI = 0.0017–0.650; p = 0.007). Conclusion Mortality of patients with RSIE needing ICU admission is high. Aminoglycosides used in combination with β-lactam or vancomycin could reduce 30 days mortality.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Inserm
Université de Lille
CHU Lille
Institut Pasteur de Lille
Université de Lille
CHU Lille
Institut Pasteur de Lille
Collections :
Research team(s) :
Glycation from inflammation to aging
Submission date :
2019-03-01T15:24:46Z
2020-03-20T16:42:48Z
2020-03-20T16:42:48Z
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