Title :

Is chronic histiocytic intervillositis a severe placental disease? a case-control study

Author(s) :

Homatter, C. [Auteur]
Hôpital Jeanne de Flandre [Lille]
Stichelbout, Morgane [Auteur]
Centre Hospitalier de Roubaix
Devisme, Louise [Auteur]
Centre Hospitalier de Roubaix
Chudzinski, A. [Auteur]
Centre Hospitalier de Roubaix
Debarge, V. [Auteur]
Hôpital Jeanne de Flandre [Lille]
Garabedian, C. [Auteur]
Hôpital Jeanne de Flandres
Subtil, Damien [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Journal title :

Placenta

Abbreviated title :

Placenta

Volume number :

91

Pages :

31-36

Publisher :

Elsevier

Publication date :

2020-02-01

ISSN :

1532-3102

Keyword(s) :

Fetal death
Comparative study
Pregnancy outcome
Placenta diseases
Small for gestational age
Fetal growth retardation

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Chronic histiocytic intervillositis (CHI) is a placental disease that has been associated with unfavorable obstetric outcomes in small, noncomparative series. The objective was to measure the excess risk of adverse obstetric ...
Show more >Chronic histiocytic intervillositis (CHI) is a placental disease that has been associated with unfavorable obstetric outcomes in small, noncomparative series. The objective was to measure the excess risk of adverse obstetric outcomes associated with the discovery of CHI after birth. Retrospective single-center case-control study from 2000 through 2016. The case patients had a CHI diagnosis after a pathology analysis of the placenta. Two types of controls were defined for each case: low-risk control women were those who gave birth in our hospital immediately before each case patient, and the high-risk controls were the next women after each case for whom microscopic examination of the placenta was indicated. We observed 111 cases of CHI during the study period. Compared with the 111 low-risk controls, the cases had a significantly higher frequency of late miscarriages (5.4 vs 0.0%, p < .03), small for gestational age (SGA) babies <3rd centile (70.4 vs 0.9%, p < .001, OR 140, 95% CI, 19.9-2800), and in utero deaths (35.1 vs 0.9%, p < .001, OR 59.6, 95% CI 8.5-1192), with significantly fewer children surviving to discharge (54.9 vs 99.1%, p < .001, OR 0.01, 95% CI, 0.00-0.08). All of these factors also differed significantly compared with the high-risk women (severe SGA: OR 3.7, 95% CI 1.9-7.0; in utero death: OR 4.1, 95% CI 1.9-8.7; children surviving to discharge: OR 0.27, 95% CI, 0.14-0.52). Even compared with high-risk pregnancies, CHI is a severe placental disease associated with a substantial excess rate of late miscarriages, severe SGA and in utero death.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Université de Lille

Collections :

• Maladies Rares du Développement : Génétique, Régulation et Protéomique (RADEME) - ULR 7364
• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Submission date :

2021-09-02T07:01:27Z
2024-03-20T10:47:41Z