Titre :

Association of chorioamnionitis with cerebral palsy at two years after spontaneous very preterm birth: the epipage-2 cohort study

Auteur(s) :

Maisonneuve, Emeline [Auteur]
Sorbonne Université [SU]
Lorthe, Elsa [Auteur]
Sorbonne Université [SU]
Torchin, Heloise [Auteur]
Université Paris Descartes - Paris 5 [UPD5]
Delorme, Pierre [Auteur]
Université Paris Descartes - Paris 5 [UPD5]
Devisme, Louise [Auteur]
Maladies Rares du Développement : Génétique, Régulation et Protéomique (RADEME) - ULR 7364
Marret, Stephane [Auteur]
Service de Pédiatrie Néonatale et Réanimation – Neuropédiatrie [CHU Rouen]
Subtil, Damien [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Bodeau-Livinec, Florence [Auteur]
École des Hautes Études en Santé Publique [EHESP] [EHESP]
Pierrat, Veronique [Auteur]
Hôpital Jeanne de Flandre [Lille]
Sentilhes, Loic [Auteur]
Université de Bordeaux [UB]
Goffinet, Francois [Auteur]
Service de Gynécologie et Obstétrique [Cochin]
Ancel, Pierre-Yves [Auteur]
AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris]
Kayem, Gilles [Auteur]
Université Paris Descartes - Paris 5 [UPD5]

Titre de la revue :

The Journal of pediatrics

Nom court de la revue :

J. Pediatr.

Numéro :

222

Pagination :

71-78.e6

Date de publication :

2020-07-01

ISSN :

1097-6833

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

To assess whether chorioamnionitis is associated with cerebral palsy (CP) or death at 2 years' corrected age in infants born before 32 weeks of gestation after spontaneous birth. EPIPAGE-2 is a national, prospective, ...
Lire la suite >To assess whether chorioamnionitis is associated with cerebral palsy (CP) or death at 2 years' corrected age in infants born before 32 weeks of gestation after spontaneous birth. EPIPAGE-2 is a national, prospective, population-based cohort study of children born preterm in France in 2011; recruitment periods varied by gestational age. This analysis includes infants born alive after preterm labor or preterm premature rupture of membranes from 240/76/7 Among 2252 infants born alive spontaneously before 32 weeks of gestation, 116 (5.2%) were exposed to clinical chorioamnionitis. Among 1470 with placental examination data available, 639 (43.5%) had histologic chorioamnionitis. In total, 346 infants died before 2 years and 1586 (83.2% of the survivors) were evaluated for CP at age 2 years. CP rates were 11.1% with and 5.0% without clinical chorioamnionitis (P = .03) and 6.1% with and 5.3% without histologic chorioamnionitis (P = .49). After adjustment for confounding factors, CP risk rose with clinical chorioamnionitis (aOR 2.13, 95% CI 1.12-4.05) but not histologic chorioamnionitis (aOR 1.21, 95% 0.75-1.93). Neither form was associated with the composite outcome "CP or death at age 2." Among infants very preterm born spontaneously, the risk of CP at a corrected age of 2 years was associated with exposure to clinical chorioamnionitis but not histologic chorioamnionitis.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
Université de Lille

Collections :

• Maladies Rares du Développement : Génétique, Régulation et Protéomique (RADEME) - ULR 7364
• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Date de dépôt :

2021-09-02T07:01:39Z
2021-10-27T07:59:10Z