Intercalation of Ciprofloxacin in Naturally ...
Document type :
Article dans une revue scientifique: Article original
DOI :
Permalink :
Title :
Intercalation of Ciprofloxacin in Naturally Occurring Smectite from Bana: Potentiality as Drug Delivery System and Antimicrobial Effects on Escherichia coli and Staphylococcus aureus
Author(s) :
Memenfo, Carine Feudjio [Auteur]
University of Yaoundé [Cameroun]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Tabary, Nicolas [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Unité Matériaux et Transformations (UMET) - UMR 8207
Mbey, Jean Aimé [Auteur]
University of Yaoundé [Cameroun]
Degoutin, Stephanie [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Unité Matériaux et Transformations (UMET) - UMR 8207
Cazaux, Frederic [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Unité Matériaux et Transformations (UMET) - UMR 8207
Bacquet, Maryse [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Unité Matériaux et Transformations (UMET) - UMR 8207
Maton, Mickael [Auteur]
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Advanced Drug Delivery Systems (ADDS) - U1008
Martel, Bernard [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Unité Matériaux et Transformations (UMET) - UMR 8207
Njopwouo, Daniel [Auteur]
University of Yaoundé [Cameroun]
University of Yaoundé [Cameroun]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Tabary, Nicolas [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Unité Matériaux et Transformations (UMET) - UMR 8207
Mbey, Jean Aimé [Auteur]
University of Yaoundé [Cameroun]
Degoutin, Stephanie [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Unité Matériaux et Transformations (UMET) - UMR 8207
Cazaux, Frederic [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Unité Matériaux et Transformations (UMET) - UMR 8207
Bacquet, Maryse [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Unité Matériaux et Transformations (UMET) - UMR 8207
Maton, Mickael [Auteur]
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Advanced Drug Delivery Systems (ADDS) - U1008
Martel, Bernard [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Unité Matériaux et Transformations (UMET) - UMR 8207
Njopwouo, Daniel [Auteur]
University of Yaoundé [Cameroun]
Journal title :
Journal of Materials Science and Chemical Engineering
Abbreviated title :
MSCE
Volume number :
09
Pages :
21-40
Publisher :
Scientific Research Publishing, Inc.
Publication date :
2021-08
ISSN :
2327-6053
English keyword(s) :
Antibacterial Effect
Drug Delivery System
Clay
Ciprofloxacin
Intercalation
Drug Delivery System
Clay
Ciprofloxacin
Intercalation
HAL domain(s) :
Chimie/Matériaux
Chimie/Polymères
Chimie/Polymères
English abstract : [en]
Ciprofloxacin (CFX) was loaded on Bana clay (Cameroon) and CFX loadedclays
have been evaluated as drug delivery system. Raw clays and CFX loaded
compounds have been characterized by some physico-chemicals methods. In
vitro ...
Show more >Ciprofloxacin (CFX) was loaded on Bana clay (Cameroon) and CFX loadedclays have been evaluated as drug delivery system. Raw clays and CFX loaded compounds have been characterized by some physico-chemicals methods. In vitro release studies have been done in gastric and phosphate buffer experimental mediums; bacteriological studies have been made up on Escherichia coli and Staphylococcus aureus. X-ray diffractometry patterns of loaded compounds show a basal spacing increasing due to CFX intercalation. On Fourier-Transformed Infrared spectrometry spectra, appearance of CFX characteristic bands and shifting of certain bands already presents on clay confirmed CFX intercalation. After 96 h of CFX released from release mediums, prolonged and continue profiles have been observed. Diffusion tests displayed an inhibition radius of ~2 cm on gelose seeded with Escherichia coli and Staphylococcus aureus due to CFX. The overall results show a modified release of ciprofloxacin with an effective antibacterial activity, giving the way for a new ciprofloxacin drug delivery system using Bana clay as carrier.Show less >
Show more >Ciprofloxacin (CFX) was loaded on Bana clay (Cameroon) and CFX loadedclays have been evaluated as drug delivery system. Raw clays and CFX loaded compounds have been characterized by some physico-chemicals methods. In vitro release studies have been done in gastric and phosphate buffer experimental mediums; bacteriological studies have been made up on Escherichia coli and Staphylococcus aureus. X-ray diffractometry patterns of loaded compounds show a basal spacing increasing due to CFX intercalation. On Fourier-Transformed Infrared spectrometry spectra, appearance of CFX characteristic bands and shifting of certain bands already presents on clay confirmed CFX intercalation. After 96 h of CFX released from release mediums, prolonged and continue profiles have been observed. Diffusion tests displayed an inhibition radius of ~2 cm on gelose seeded with Escherichia coli and Staphylococcus aureus due to CFX. The overall results show a modified release of ciprofloxacin with an effective antibacterial activity, giving the way for a new ciprofloxacin drug delivery system using Bana clay as carrier.Show less >
Language :
Anglais
Peer reviewed article :
Oui
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Université de Lille
CNRS
INRA
ENSCL
CNRS
INRA
ENSCL
Collections :
Research team(s) :
Ingénierie des Systèmes Polymères
Submission date :
2021-09-02T13:29:32Z
2021-09-03T09:03:16Z
2022-10-11T08:52:01Z
2022-10-11T08:54:39Z
2022-10-11T09:40:15Z
2021-09-03T09:03:16Z
2022-10-11T08:52:01Z
2022-10-11T08:54:39Z
2022-10-11T09:40:15Z
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