Titre :

Intercalation of Ciprofloxacin in Naturally Occurring Smectite from Bana: Potentiality as Drug Delivery System and Antimicrobial Effects on Escherichia coli and Staphylococcus aureus

Auteur(s) :

Memenfo, Carine Feudjio [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
University of Yaoundé [Cameroun]
Tabary, Nicolas [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Unité Matériaux et Transformations - UMR 8207 [UMET]
Mbey, Jean Aimé [Auteur]
University of Yaoundé [Cameroun]
Degoutin, Stephanie [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Unité Matériaux et Transformations - UMR 8207 [UMET]
Cazaux, Frederic [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Unité Matériaux et Transformations - UMR 8207 [UMET]
Bacquet, Maryse [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Unité Matériaux et Transformations - UMR 8207 [UMET]
Maton, Mickael [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Martel, Bernard [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Unité Matériaux et Transformations - UMR 8207 [UMET]
Njopwouo, Daniel [Auteur]
University of Yaoundé [Cameroun]

Titre de la revue :

Journal of Materials Science and Chemical Engineering

Nom court de la revue :

MSCE

Numéro :

09

Pagination :

21-40

Éditeur :

Scientific Research Publishing, Inc.

Date de publication :

2021-08

ISSN :

2327-6053

Mot(s)-clé(s) en anglais :

Antibacterial Effect
Drug Delivery System
Clay
Ciprofloxacin
Intercalation

Discipline(s) HAL :

Chimie/Matériaux
Chimie/Polymères

Résumé en anglais : [en]

Ciprofloxacin (CFX) was loaded on Bana clay (Cameroon) and CFX loadedclays have been evaluated as drug delivery system. Raw clays and CFX loaded compounds have been characterized by some physico-chemicals methods. In vitro ...
Lire la suite >Ciprofloxacin (CFX) was loaded on Bana clay (Cameroon) and CFX loadedclays have been evaluated as drug delivery system. Raw clays and CFX loaded compounds have been characterized by some physico-chemicals methods. In vitro release studies have been done in gastric and phosphate buffer experimental mediums; bacteriological studies have been made up on Escherichia coli and Staphylococcus aureus. X-ray diffractometry patterns of loaded compounds show a basal spacing increasing due to CFX intercalation. On Fourier-Transformed Infrared spectrometry spectra, appearance of CFX characteristic bands and shifting of certain bands already presents on clay confirmed CFX intercalation. After 96 h of CFX released from release mediums, prolonged and continue profiles have been observed. Diffusion tests displayed an inhibition radius of ~2 cm on gelose seeded with Escherichia coli and Staphylococcus aureus due to CFX. The overall results show a modified release of ciprofloxacin with an effective antibacterial activity, giving the way for a new ciprofloxacin drug delivery system using Bana clay as carrier.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
CNRS
INRA
ENSCL

Collections :

• Advanced Drug Delivery Systems (ADDS) - U1008
• Unité Matériaux et Transformations (UMET) - UMR 8207

Équipe(s) de recherche :

Ingénierie des Systèmes Polymères

Date de dépôt :

2021-09-02T13:29:32Z
2021-09-03T09:03:16Z
2022-10-11T08:52:01Z
2022-10-11T08:54:39Z
2022-10-11T09:40:15Z