Pathogenicity and virulence of Bordetella ...
Type de document :
Compte-rendu et recension critique d'ouvrage
PMID :
Titre :
Pathogenicity and virulence of Bordetella pertussis and its adaptation to its strictly human host
Auteur(s) :
Belcher, Thomas [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Dubois, Violaine [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Rivera-Millot, Alex [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Locht, Camille [Auteur correspondant]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Jacob, Francoise [Auteur correspondant]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Dubois, Violaine [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Rivera-Millot, Alex [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Locht, Camille [Auteur correspondant]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Jacob, Francoise [Auteur correspondant]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Titre de la revue :
Virulence
Pagination :
2608-2632
Éditeur :
Taylor & Francis
Date de publication :
2021-09-30
ISSN :
2150-5594
Mot(s)-clé(s) en anglais :
Pertussis
Bordetella
metabolism
virulence factors
evolution
adaptive immunity
innate immunity
Bordetella
metabolism
virulence factors
evolution
adaptive immunity
innate immunity
Discipline(s) HAL :
Sciences du Vivant [q-bio]/Microbiologie et Parasitologie/Bactériologie
Résumé en anglais : [en]
The highly contagious whooping cough agent Bordetella pertussis has evolved as a humanrestricted pathogen from a progenitor which also gave rise to Bordetella parapertussis and Bordetella bronchiseptica. While the latter ...
Lire la suite >The highly contagious whooping cough agent Bordetella pertussis has evolved as a humanrestricted pathogen from a progenitor which also gave rise to Bordetella parapertussis and Bordetella bronchiseptica. While the latter colonizes a broad range of mammals and is able to survive in the environment, B. pertussis has lost its ability to survive outside its host through massive genome decay. Instead, it has become a highly successful human pathogen by the acquisition of tightly regulated virulence factors and evolutionary adaptation of its metabolism to its particular niche. By the deployment of an arsenal of highly sophisticated virulence factors it overcomes many of the innate immune defenses. It also interferes with vaccine-induced adaptive immunity by various mechanisms. Here, we review data from in vitro, human and animal models to illustrate the mechanisms of adaptation to the human respiratory tract and provide evidence of ongoing evolutionary adaptation as a highly successful human pathogen.Lire moins >
Lire la suite >The highly contagious whooping cough agent Bordetella pertussis has evolved as a humanrestricted pathogen from a progenitor which also gave rise to Bordetella parapertussis and Bordetella bronchiseptica. While the latter colonizes a broad range of mammals and is able to survive in the environment, B. pertussis has lost its ability to survive outside its host through massive genome decay. Instead, it has become a highly successful human pathogen by the acquisition of tightly regulated virulence factors and evolutionary adaptation of its metabolism to its particular niche. By the deployment of an arsenal of highly sophisticated virulence factors it overcomes many of the innate immune defenses. It also interferes with vaccine-induced adaptive immunity by various mechanisms. Here, we review data from in vitro, human and animal models to illustrate the mechanisms of adaptation to the human respiratory tract and provide evidence of ongoing evolutionary adaptation as a highly successful human pathogen.Lire moins >
Langue :
Anglais
Vulgarisation :
Non
Source :
Fichiers
- https://hal.archives-ouvertes.fr/hal-03359729/document
- Accès libre
- Accéder au document
- https://hal.archives-ouvertes.fr/hal-03359729/document
- Accès libre
- Accéder au document
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8489951/pdf
- Accès libre
- Accéder au document
- https://hal.archives-ouvertes.fr/hal-03359729/document
- Accès libre
- Accéder au document
- document
- Accès libre
- Accéder au document
- Pathogenicity%20and%20virulence%20of%20Bordetella%20pertussis%20and%20its%20adaptation%20to%20its%20strictly%20human%20host.pdf
- Accès libre
- Accéder au document
- Accès libre
- Accéder au document