Title :

Polydopamine treatment of chitosan nanofibers for the conception of osteoinductive scaffolds for bone reconstruction

Author(s) :

Dimassi, Syrine [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Tabary, Nicolas [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Chai, Feng [Auteur]
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Zobrist, Cedric [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Hornez, Jean-Christophe [Auteur]
Laboratoire des Matériaux Céramiques et Procédés Associés - EA 2443 [LMCPA]
Cazaux, Frederic [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Blanchemain, Nicolas [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Martel, Bernard [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207

Journal title :

Carbohydrate Polymers

Abbreviated title :

Carbohydrate Polymers

Volume number :

276

Pages :

118774

Publisher :

Elsevier BV

Publication date :

2022

ISSN :

0144-8617

English keyword(s) :

Electrospinning
Nanofibers
Polydopamine
Scaffolds
Hydroxyapatite
Bone tissue engineering

HAL domain(s) :

Chimie/Polymères

English abstract : [en]

We report the influence of treatment time of electrospun chitosan nanofibers (CHT NFs) in dopamine hydrochloride bath (2 mg.mL−1 in 10 mM Tris buffer, pH 8.5) on the extent of the polydopamine (pDA) coating on NFs surface. ...
Show more >We report the influence of treatment time of electrospun chitosan nanofibers (CHT NFs) in dopamine hydrochloride bath (2 mg.mL−1 in 10 mM Tris buffer, pH 8.5) on the extent of the polydopamine (pDA) coating on NFs surface. The reaction was characterized by FTIR and SEM analysis and the cytocompatibility of the scaffolds toward MT3C3-E1 cells was assessed. Biomimetic deposition of hydroxyapatite (HA) in 1.5xSBF batch was investigated by SEM-EDS and XRD. Samples treated in dopamine bath during 2 h promoted the structural stability of NFs in PBS, provided optimal cytocompatibility and induced the in vitro biomineralization from 6 days in 1.5xSBF. The XRD and SEM-EDS investigations confirmed formation of spherical-shaped particles composed of apatitic phase. Finally, this study shows that these NFs-pDA scaffolds prepared in the optimal experimental conditions defined here are promising candidates for application as osteoinductive scaffolds for bone regeneration applied to orthopedic and dental applications.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Non spécifiée

Administrative institution(s) :

Université de Lille
CNRS
INRA
ENSCL

Collections :

• Unité Matériaux et Transformations (UMET) - UMR 8207

Research team(s) :

Ingénierie des Systèmes Polymères

Submission date :

2021-10-26T06:56:51Z
2021-10-26T07:03:11Z
2021-10-26T07:08:50Z
2021-10-27T06:18:11Z
2021-10-27T06:19:55Z
2021-10-27T06:21:53Z
2021-10-28T10:20:55Z