Title :

Influenza Virus Infection Impairs the Gut’s Barrier Properties and Favors Secondary Enteric Bacterial Infection through Reduced Production of Short-Chain Fatty Acids

Author(s) :

Sencio, Valentin [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Gallerand, Alexandre [Auteur]
Centre méditerranéen de médecine moléculaire [C3M]
Gomes Machado, Marina [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Deruyter, Lucie [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Heumel, Séverine [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Soulard, Daphnée [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Barthelemy, Johanna [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Cuinat, Céline [Auteur]
MICrobiologie de l'ALImentation au Service de la Santé [MICALIS]
Vieira, Angelica [Auteur]
Centre méditerranéen de médecine moléculaire [C3M]
Barthelemy, Adeline [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Tavares, Luciana [Auteur]
Centre méditerranéen de médecine moléculaire [C3M]
Guinamard, Rodolphe r. [Auteur]
Ivanov, Stoyan [Auteur]
Grangette, Corinne [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Teixeira, Mauro [Auteur]
Centre méditerranéen de médecine moléculaire [C3M]
Foligné, Benoit [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Wolowczuk, Isabelle [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Le Goffic, Ronan [Auteur]
Virologie et Immunologie Moléculaires [VIM (UR 0892)]
Thomas, Muriel [Auteur]
MICrobiologie de l'ALImentation au Service de la Santé [MICALIS]
Trottein, Francois [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]

Journal title :

Infection and Immunity

Publisher :

American Society for Microbiology

Publication date :

2021

ISSN :

0019-9567

English keyword(s) :

influenza
gut microbial dysbiosis
enteric infection
bacterial translocation
short-chain fatty acids

HAL domain(s) :

Sciences du Vivant [q-bio]/Immunologie

English abstract : [en]

Along with respiratory tract disease per se, viral respiratory infections can also cause extrapulmonary complications with a potentially critical impact on health. In the present study, we used an experimental model of ...
Show more >Along with respiratory tract disease per se, viral respiratory infections can also cause extrapulmonary complications with a potentially critical impact on health. In the present study, we used an experimental model of influenza A virus (IAV) infection to investigate the nature and outcome of the associated gut disorders. In IAV-infected mice, the signs of intestinal injury and inflammation, altered gene expression, and compromised intestinal barrier functions peaked on day 7 postinfection. As a likely result of bacterial component translocation, gene expression of inflammatory markers was upregulated in the liver. These changes occurred concomitantly with an alteration of the composition of the gut microbiota and with a decreased production of the fermentative, gut microbiota-derived products short-chain fatty acids (SCFAs). Gut inflammation and barrier dysfunction during influenza were not attributed to reduced food consumption, which caused in part gut dysbiosis. Treatment of IAV-infected mice with SCFAs was associated with an enhancement of intestinal barrier properties, as assessed by a reduction in the translocation of dextran and a decrease in inflammatory gene expression in the liver. Lastly, SCFA supplementation during influenza tended to reduce the translocation of the enteric pathogen Salmonella enterica serovar Typhimurium and to enhance the survival of doubly infected animals. Collectively, influenza virus infection can remotely impair the gut's barrier properties and trigger secondary enteric infections. The latter phenomenon can be partially countered by SCFA supplementation.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

ANR Project :

Rôle de l'axe poumon/intestin/moelle osseuse et du microbiote au cours de la grippe

Collections :

• Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017

Source :

Harvested from HAL