Acute Effects of Cocoa Flavanols on Blood ...
Document type :
Article dans une revue scientifique: Article original
DOI :
PMID :
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Title :
Acute Effects of Cocoa Flavanols on Blood Pressure and Peripheral Vascular Reactivity in Type 2 Diabetes Mellitus and Essential Hypertension: A Protocol for an Acute, Randomized, Double-Blinded, Placebo-Controlled Cross-Over Trial.
Author(s) :
Tanghe, Anouk [Auteur]
Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369 - ULR 4488 [URePSSS]
Celie, Bert [Auteur]
Universiteit Gent = Ghent University [UGENT]
Shadid, Samyah [Auteur]
Universiteit Gent = Ghent University [UGENT]
Rietzschel, Ernst [Auteur]
Universiteit Gent = Ghent University [UGENT]
Op 't Roodt, Jos [Auteur]
Maastricht University [Maastricht]
Reesink, Koen D [Auteur]
Maastricht University [Maastricht]
Heyman, Elsa [Auteur]
Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369
Calders, Patrick [Auteur]
Universiteit Gent = Ghent University [UGENT]
Tanghe, Anouk [Auteur]
Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369 - ULR 4488 [URePSSS]
Celie, Bert [Auteur]
Universiteit Gent = Ghent University [UGENT]
Shadid, Samyah [Auteur]
Universiteit Gent = Ghent University [UGENT]
Rietzschel, Ernst [Auteur]
Universiteit Gent = Ghent University [UGENT]
Op 't Roodt, Jos [Auteur]
Maastricht University [Maastricht]
Reesink, Koen D [Auteur]
Maastricht University [Maastricht]
Heyman, Elsa [Auteur]
Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369
Calders, Patrick [Auteur]
Universiteit Gent = Ghent University [UGENT]
Tanghe, Anouk [Auteur]
Journal title :
Frontiers in cardiovascular medicine
Abbreviated title :
Front Cardiovasc Med
Volume number :
8
Pages :
602086
Publication date :
2021-03-15
ISSN :
2297-055X
English keyword(s) :
antihypertensive drugs
blood pressure
cocoa flavanols
muscular oxygenation
type 2 diabetes
vascular reactivity
blood pressure
cocoa flavanols
muscular oxygenation
type 2 diabetes
vascular reactivity
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Patients with type 2 diabetes mellitus are at high risk to develop vascular complications resulting in high morbidity and mortality. Cocoa flavanols are promising nutraceuticals with possible beneficial vascular effects ...
Show more >Patients with type 2 diabetes mellitus are at high risk to develop vascular complications resulting in high morbidity and mortality. Cocoa flavanols are promising nutraceuticals with possible beneficial vascular effects in humans. However, limited research is currently available on the vascular effects in a diabetic population with inconsistent results. Possible reasons for this inconsistency might be heterogeneity in the given intervention (dose per time and day, single dose vs. split-dose, placebo formula) and the studied population (blood pressure at baseline, duration of diabetes, use of vasoactive antihypertensive and antidiabetic drugs, sex). Therefore, we aimed to develop a randomized, double-blinded, placebo-controlled cross-over trial to investigate whether cocoa flavanols have an acute impact on blood pressure and vascular reactivity in patients with type 2 diabetes with and without arterial hypertension. We will include participants in four groups: (i) patients with type 2 diabetes without arterial hypertension, (ii) patients with type 2 diabetes with arterial hypertension and 1 antihypertensive drug, (iii) non-diabetic participants with essential hypertension and 1 antihypertensive drug, and (iv) healthy controls. All participants will complete the same protocol on both testing days, consuming high-flavanol cocoa extract (790 mg flavanols) or placebo. Macrovascular endothelial function (flow-mediated dilation) and blood pressure will be measured before and after capsule ingestion. Forearm muscle vasoreactivity (near-infrared spectroscopy) and brachial artery blood flow (echo-doppler) will be assessed in response to a dynamic handgrip exercise test after capsule ingestion. Data will be analyzed with a random intercept model in mixed models. www.Clinicaltrials.gov, identifier: NCT03722199.Show less >
Show more >Patients with type 2 diabetes mellitus are at high risk to develop vascular complications resulting in high morbidity and mortality. Cocoa flavanols are promising nutraceuticals with possible beneficial vascular effects in humans. However, limited research is currently available on the vascular effects in a diabetic population with inconsistent results. Possible reasons for this inconsistency might be heterogeneity in the given intervention (dose per time and day, single dose vs. split-dose, placebo formula) and the studied population (blood pressure at baseline, duration of diabetes, use of vasoactive antihypertensive and antidiabetic drugs, sex). Therefore, we aimed to develop a randomized, double-blinded, placebo-controlled cross-over trial to investigate whether cocoa flavanols have an acute impact on blood pressure and vascular reactivity in patients with type 2 diabetes with and without arterial hypertension. We will include participants in four groups: (i) patients with type 2 diabetes without arterial hypertension, (ii) patients with type 2 diabetes with arterial hypertension and 1 antihypertensive drug, (iii) non-diabetic participants with essential hypertension and 1 antihypertensive drug, and (iv) healthy controls. All participants will complete the same protocol on both testing days, consuming high-flavanol cocoa extract (790 mg flavanols) or placebo. Macrovascular endothelial function (flow-mediated dilation) and blood pressure will be measured before and after capsule ingestion. Forearm muscle vasoreactivity (near-infrared spectroscopy) and brachial artery blood flow (echo-doppler) will be assessed in response to a dynamic handgrip exercise test after capsule ingestion. Data will be analyzed with a random intercept model in mixed models. www.Clinicaltrials.gov, identifier: NCT03722199.Show less >
Peer reviewed article :
Oui
Audience :
Internationale
Administrative institution(s) :
Université de Lille
Univ. Artois
Univ. Littoral Côte d’Opale
Univ. Artois
Univ. Littoral Côte d’Opale
Research team(s) :
Activité Physique, Muscle, Santé (APMS)
Submission date :
2021-11-06T13:57:58Z
2021-11-10T08:33:55Z
2021-11-10T08:33:55Z
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