Titre :

Donepezil increases contrast sensitivity for the detection of objects in scenes

Auteur(s) :

Boucart, Muriel [Auteur]
Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193
Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab]
Bubbico, Giovanna [Auteur]
Defoort, Sabine [Auteur]
Szaffarczyk, Sébastien [Auteur]
Ponchel, Amelie [Auteur]
Waucquier, Nawal [Auteur]
Deplanque, Dominique [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Deguil, Julie [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Bordet, Regis [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]

Titre de la revue :

Behavioural Brain Research

Nom court de la revue :

Behav. Brain Res.

Numéro :

292

Pagination :

443-447

Date de publication :

2015-10-01

ISSN :

1872-7549

Discipline(s) HAL :

Sciences cognitives

Résumé en anglais : [en]

We assessed the effects of donepezil, a drug that stimulates cholinergic transmission, and scopolamine, an antagonist of cholinergic transmission, on contrast sensitivity. 30 young male participants were tested under three ...
Lire la suite >We assessed the effects of donepezil, a drug that stimulates cholinergic transmission, and scopolamine, an antagonist of cholinergic transmission, on contrast sensitivity. 30 young male participants were tested under three treatment conditions: placebo, donepezil, and scopolamine in a random order. Pairs of photographs varying in contrast were displayed left and right of fixation for 50 ms. Participants were asked to locate the scene containing an animal. Accuracy was better under donepezil than under scopolamine, particularly for signals of high intensity (at higher levels of contrast). A control experiment showed that the lower performance under scopolamine did not result from the mydriasis induced by scopolamine. The results suggest that cholinergic stimulation, through donepezil, facilitates signal detection in agreement with studies on animals showing that the pharmacological activation of cholinergic receptors controls the gain in the relationship between the stimulus contrast (intensity of the visual input) and visual response. As Alzheimer disease is associated to depletion in acetylcholine, and there is evidence of deficits in contrast sensitivity in Alzheimer, it might be interesting to integrate such rapid and sensitive visual tasks in the biomarkers at early stage of drug development.Lire moins >

Langue :

Anglais

Audience :

Non spécifiée

Vulgarisation :

Non

Établissement(s) :

Université de Lille
CNRS
CHU Lille
Inserm

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172
• Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193

Équipe(s) de recherche :

Équipe Action, Vision et Apprentissage (AVA)

Date de dépôt :

2019-03-08T14:44:44Z
2019-11-08T10:51:50Z
2025-01-17T10:42:58Z