Title :

The ability of early changes in motivation to predict later antidepressant treatment response

Author(s) :

Gorwood, Philip [Auteur]
Centre de Psychiatrie et Neurosciences [U894]
Vaiva, Guillaume [Auteur]
Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab]
Corruble, Emmanuelle [Auteur]
Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
Llorca, Pierre-Michel [Auteur]
Neuro-Psycho Pharmacologie des Systèmes Dopaminergiques sous-corticaux [NPsy-Sydo]
Bayle, Frank [Auteur]
Université Paris Descartes - Paris 5 [UPD5]
Centre de Psychiatrie et Neurosciences [U894]
Courtet, Philippe [Auteur]
Neuropsychiatrie : recherche épidémiologique et clinique [PSNREC]

Journal title :

Neuropsychiatric Disease and Treatment

Abbreviated title :

Neuropsychiatr Dis Treat

Volume number :

11

Pages :

2875-2882

Publication date :

2015-09

ISSN :

1176-6328

HAL domain(s) :

Sciences cognitives

English abstract : [en]

INTRODUCTION: Baseline values and early changes of emotional reactivity, cognitive speed, psychomotor function, motivation, and sensory perception have not been studied to any extent in unipolar depression, although they ...
Show more >INTRODUCTION: Baseline values and early changes of emotional reactivity, cognitive speed, psychomotor function, motivation, and sensory perception have not been studied to any extent in unipolar depression, although they could help to characterize different dimensions of illness that are harder to capture by clinicians, give new insights on how patients improve, and offer new early clinical markers for later treatment response. METHODS: About 1,565 adult outpatients with major depressive disorder receiving agomelatine completed the clinician-rated 16-item quick inventory of depressive symptoms, Clinical Global Impression, and Multidimensional Assessment of Thymic States (MAThyS) rating scales at inclusion, Week 2 and Week 6. The MAThyS includes a 20-item self-rated visual analog scale (from inhibition [0] to activation [10], with [5] representing the usual state) leading to five a priori dimensions (emotional reactivity, cognitive speed, psychomotor function, motivation, and sensory perception). RESULTS: All MAThyS dimension scores increased from inclusion to Week 2 and from inclusion to Week 6 (P<0.001). Improvement was around 2 points (out of 10) for motivation, 1.5 points for psychomotor function, and 0.5 points for other dimensions. Motivation showed a trend to being more severely impaired at inclusion in future nonresponders (t=1.25, df=1,563, P=0.10). Its improvement at Week 2 was the most discriminating MAThyS dimension between future responders and nonresponders, and represents the best predictor of future response, with the highest area under the receptor operating characteristic curve (area under curve =0.616, 95% confidence interval [0.588-0.643], P<0.001). Finally, improvements in motivation correlated the most strongly with clinician-rated 16-item quick inventory of depressive symptoms improvement (r=-0.491, df=1,563, P<0.001). CONCLUSION: Motivation had the most capacity for early improvement, the best predictive value for response, and the largest global margin of progress in depressed outpatients. Assessing the evolution of self-reported motivation over time in major depressive disorder could offer an interesting complementary approach to predict response.Show less >

Language :

Anglais

Audience :

Non spécifiée

Administrative institution(s) :

Université de Lille
CNRS
CHU Lille

Collections :

• Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193

Research team(s) :

Équipe Psychiatrie & Croyance (PsyCHIC)

Submission date :

2019-03-08T14:46:17Z
2019-10-22T15:28:21Z
2020-03-12T10:04:16Z
2020-03-19T10:50:39Z