Titre :

An increase in joy after two weeks is more specific of later antidepressant response than a decrease in sadness

Auteur(s) :

Gorwood, P. [Auteur]
Centre de Psychiatrie et Neurosciences [U894]
Université Paris Descartes - Paris 5 [UPD5]
Centre Hospitalier Sainte Anne [Paris]
Demyttenare, K. [Auteur]
Catholic University of Leuven = Katholieke Universiteit Leuven [KU Leuven]
Vaiva, Guillaume [Auteur]
Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab]
Corruble, E. [Auteur]
Santé mentale et santé publique [SMSP - U1178]
Llorca, P.-M. [Auteur]
CHU Clermont-Ferrand
Bayle, F. [Auteur]
Université Paris Descartes - Paris 5 [UPD5]
Centre Hospitalier Sainte Anne [Paris]
Courtet, P. [Auteur]
Centre Hospitalier Régional Universitaire [Montpellier] [CHRU Montpellier]
Université de Montpellier [UM]

Titre de la revue :

Journal of Affective Disorders

Nom court de la revue :

J Affect Disord

Numéro :

185

Pagination :

97-103

Date de publication :

2015-10-01

ISSN :

1573-2517

Discipline(s) HAL :

Sciences cognitives

Résumé en anglais : [en]

BACKGROUND: Early improvement in positive emotions-more than decreases in negative emotions-was highly predictive of treatment response in an ecologically valid prospective manner. This result needs replication with simpler ...
Lire la suite >BACKGROUND: Early improvement in positive emotions-more than decreases in negative emotions-was highly predictive of treatment response in an ecologically valid prospective manner. This result needs replication with simpler assessments to determine whether it can be translated into clinical practice. METHODS: 2049 adult depressed outpatients receiving agomelatine were assessed at inclusion, week 2, and week 6 using the clinician-rated Quick Inventory of Depressive Symptomatology, Sheehan Disability Scale, Clinical Global Impression scale, and Multidimensional Assessment of Thymic States (MATHYS), an auto-questionnaire rating the frequency of emotions, including sadness and joy, over the previous week. RESULTS: Joy and sadness had a relatively low correlation coefficient at baseline (r=-0.277), joy (r=-0.160) being less correlated with clinical severity than sadness (r=0.317). An increase in joy at week 2 had higher specificity (85.04%) and positive predictive value (70.55%) for treatment response than decreased sadness (57.92% and 66.04%, respectively), and the global capacity of the former to predict remission, either clinical (Yule Q coefficient, 39.96%) or functional (44.35%), was even better compared to the prediction of clinical response (37.38%). LIMITATIONS: MATHYS retrospectively assesses emotions, with five possible ratings only, relying on self-rated frequencies. With only a 6-week follow-up, conclusions are limited to short-term aspects of clinical and functional remission. CONCLUSIONS: Early improvement in joy during the first 2 weeks of treatment is strongly specific for treatment response and remission. The frequency of joy captures the predictivity and may deserve further study regarding inclusion in depressive rating scales.Lire moins >

Langue :

Anglais

Audience :

Non spécifiée

Établissement(s) :

Université de Lille
CNRS
CHU Lille

Collections :

• Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193

Équipe(s) de recherche :

Équipe Psychiatrie & Croyance (PsyCHIC)

Date de dépôt :

2019-03-08T14:46:18Z
2020-03-03T15:59:22Z