Multiple Selection Criteria for Probiotic Strains with High Potential for Obesity Management

Alard, Jeanne; Cudennec, Benoit; Boutillier, Denise; Peucelle, Véronique; Descat, Amandine; Decoin, Raphaël; Kuylle, Sarah; Jablaoui, Amin; Rhimi, Moez; Wolowczuk, Isabelle; Pot, Bruno; Tailleux, Anne; Maguin, Emmanuelle; Holowacz, Sophie; Grangette, Corinne

Document type :

Article dans une revue scientifique: Article original

DOI :

10.3390/nu13030713

PMID :

33668212

Title :

Multiple Selection Criteria for Probiotic Strains with High Potential for Obesity Management

Author(s) :

Alard, Jeanne [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Cudennec, Benoit [Auteur]

BioEcoAgro - Equipe 7 - Health benefit of protein hydrolysates and agro-food co-products: control of production, characterization and valorisation
Boutillier, Denise [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Peucelle, Véronique [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Descat, Amandine [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Decoin, Raphaël [Auteur]
Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U 1011 [RNMCD]
Kuylle, Sarah [Auteur]
Genibio [Lorp-Sentaraille]
Jablaoui, Amin [Auteur]
MICrobiologie de l'ALImentation au Service de la Santé [MICALIS]
Rhimi, Moez [Auteur]
MICrobiologie de l'ALImentation au Service de la Santé [MICALIS]
Wolowczuk, Isabelle [Auteur]

Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Pot, Bruno [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Tailleux, Anne [Auteur]
Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U 1011 [RNMCD]
Maguin, Emmanuelle [Auteur]
MICrobiologie de l'ALImentation au Service de la Santé [MICALIS]
Holowacz, Sophie [Auteur]
PiLeJe Laboratoire
Grangette, Corinne [Auteur correspondant]

Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]

Journal title :

Nutrients

Pages :

713

Publisher :

MDPI

Publication date :

2021-03

ISSN :

2072-6643

English keyword(s) :

enteroendocrine peptides
epithelial barrier
inflammation
obesity
microbiota
probiotics
hypothalamus
bile acids

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Since alterations of the gut microbiota have been shown to play a major role in obesity, probiotics have attracted attention. Our aim was to identify probiotic candidates for the management of obesity using a combination ...
Show more >Since alterations of the gut microbiota have been shown to play a major role in obesity, probiotics have attracted attention. Our aim was to identify probiotic candidates for the management of obesity using a combination of in vitro and in vivo approaches. We evaluated in vitro the ability of 23 strains to limit lipid accumulation in adipocytes and to enhance the secretion of satiety-promoting gut peptide in enteroendocrine cells. Following the in vitro screening, selected strains were further investigated in vivo, single, or as mixtures, using a murine model of diet-induced obesity. Strain Bifidobacterium longum PI10 administrated alone and the mixture of B. animalis subsp. lactis LA804 and Lactobacillus gasseri LA806 limited body weight gain and reduced obesity-associated metabolic dysfunction and inflammation. These protective effects were associated with changes in the hypothalamic gene expression of leptin and leptin receptor as well as with changes in the composition of gut microbiota and the profile of bile acids. This study provides crucial clues to identify new potential probiotics as effective therapeutic approaches in the management of obesity, while also providing some insights into their mechanisms of action.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :