Title :

Differential risk of severe infection in febrile neutropenia among children with blood cancer or solid tumor

Author(s) :

Delebarre, Mathilde [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Dessein, Rodrigue [Auteur]
Recherche translationnelle : relations hôte-pathogènes - EA 7366
Lagrée, Marion [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Mazingue, Françoise [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Sudour-Bonnange, Hélène [Auteur]
Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] [UNICANCER/Lille]
Martinot, Alain [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Dubos, Francois [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Journal title :

Journal of Infection

Abbreviated title :

Journal of Infection

Volume number :

79

Pages :

95-100

Publisher :

WB Saunders

Publication date :

2019-08

ISSN :

01634453

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Objective To describe and analyze the differences between infections in children with febrile neutropenia (FN) treated for solid tumor or blood cancer. Methods A prospective study included all episodes of FN in children ...
Show more >Objective To describe and analyze the differences between infections in children with febrile neutropenia (FN) treated for solid tumor or blood cancer. Methods A prospective study included all episodes of FN in children from April 2007 to April 2016 in 2-pediatric cancer centers in France. Medical history, clinical and laboratory data available at admission and final microbiological data were collected. The proportion of FN, severe infection, categories of microorganisms and outcomes were compared between the two groups. The presumed gateway of the infection was a posteriori considered and evaluated. Results We analyzed 1197 FN episodes (mean age: 8 years). 66% of the FN episodes occurred in children with blood cancer. Severe infections were identified in 23.4% of episodes overall. The rate of severe infection (28.4% vs. 10.4%), types of microorganisms and the need for a management in intensive care unit (2.6% vs. 0.5%) was significantly different between children with blood cancer and solid tumor. Digestive or respiratory presumed gateway of the infections was less frequent for patients with solid tumor. Conclusion Given these important microbiological and clinical differences, it may be appropriate to consider differently the risk of severe infection in these two populations and therefore the management of FN.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Institut Pasteur de Lille
Université de Lille

Collections :

• Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017
• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Submission date :

2021-12-08T09:52:20Z
2024-04-02T13:55:07Z