Traces pilot pharmacokinetic study dataset

Gilliot, Sixtine; Ducloy, Anne-Sophie; Hennart, Benjamin; Loingeville, Florence; JEANNE, MATHIEU; Lebuffe, Gilles; Odou, Pascal

Document type :

Article dans une revue scientifique: Article original

DOI :

10.1016/j.dib.2020.106474

PMID :

PMC7677109

Permalink :

http://hdl.handle.net/20.500.12210/58357

Title :

Traces pilot pharmacokinetic study dataset

Author(s) :

Gilliot, Sixtine [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Ducloy, Anne-Sophie [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Hennart, Benjamin [Auteur]

IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Loingeville, Florence [Auteur]

METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
JEANNE, MATHIEU [Auteur]

Groupe de Recherche sur les formes Injectables et les Technologies Associées (GRITA) - ULR 7365
Lebuffe, Gilles [Auteur]

Groupe de Recherche sur les formes Injectables et les Technologies Associées (GRITA) - ULR 7365
Odou, Pascal [Auteur]

Groupe de Recherche sur les formes Injectables et les Technologies Associées (GRITA) - ULR 7365

Journal title :

Data in Brief

Abbreviated title :

Data in Brief

Volume number :

Pages :

106474

Publisher :

New York Elsevier Inc.

Publication date :

2020-12

ISSN :

2352-3409

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

The dataset displays the pharmacokinetics data obtained from the TRACES pilot study. The nine patients included were undergoing haemorrhagic caesarean section (blood loss > 800 mL) and receiving a single i.v dose of ...
Show more >The dataset displays the pharmacokinetics data obtained from the TRACES pilot study. The nine patients included were undergoing haemorrhagic caesarean section (blood loss > 800 mL) and receiving a single i.v dose of tranexamic acid (0.5, 1 or 2 g over 1 min). The dataset gathers the tranexamic acid blood and urinary concentrations. With these first elements, a pharmacokinetic compartment model was built as described in Gilliot et al. and the individual pharmacokinetic parameters were estimated. In parallel, the patients anthropometric, biological, and clinical characteristics were collected. The correlation between the patient data and the estimated individual pharmacokinetic parameters were tested. The correlation tests revealed that the dose, the height, the body weight, and the ideal bodyweight had and impact on the volume of distribution of tranexamic acid. According to these results, these latter covariates were explored using a multi-regression analysis in Gilliot et al.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Institut Pasteur de Lille
Université de Lille

Collections :

Submission date :

2021-12-08T09:53:50Z
2022-01-12T10:58:47Z
2022-08-24T07:04:43Z

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Except where otherwise noted, this item's license is described as Attribution 3.0 United States

Version	Link	Modification date
3	20.500.12210/58357*	2022-08-24T06:59:39Z
2	20.500.12210/58357.2	2022-01-12T10:51:21Z
1	20.500.12210/58357.1	2021-12-08T09:53:50Z

Traces pilot pharmacokinetic study dataset

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Traces pilot pharmacokinetic study dataset

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