Title :

Treatments for Crohn’s Disease–Associated Bowel Damage: A Systematic Review

Author(s) :

Pariente, Benjamin [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Hu, Shurong [Auteur]
Bettenworth, Dominik [Auteur]
Speca, Silvia [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Desreumaux, Pierre [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Meuwis, Marie-Alice [Auteur]
Danese, Silvio [Auteur]
Rieder, Florian [Auteur]
Louis, Edouard [Auteur]

Journal title :

Clinical Gastroenterology and Hepatology

Abbreviated title :

Clinical Gastroenterology and Hepatology

Volume number :

17

Pages :

847-856

Publication date :

2019-04

ISSN :

15423565

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Background & Aims: Despite significant advances in the treatment of Crohn’s disease (CD), most patients still develop stricturing or penetrating complications that require surgical resections. We performed a systematic ...
Show more >Background & Aims: Despite significant advances in the treatment of Crohn’s disease (CD), most patients still develop stricturing or penetrating complications that require surgical resections. We performed a systematic review of mechanisms and potential treatments for tissue damage lesions in CD patients. Methods: We searched the PubMed, MBASE, and Cochrane databases from January 1960 to July 2017 for full-length articles on CD, fibrosis, damage lesions, mesenchymal stem cells, and/or treatment. We also searched published conference abstracts and performed manual searches of all reference lists of relevant articles. Results: Mechanisms of intestinal damage in patients with CD include fibroblast proliferation and migration, activation of stellate cells, recruitment of intestinal or extra-intestinal fibroblast, and cell trans-differentiation. An altered balance of metalloproteinases and tissue inhibitors of metalloproteinases might contribute to fistula formation. Treatment approaches that reduce excessive transforming growth factor beta (TGFB) activation might be effective in treating established intestinal damage. Stem cell therapies have been effective in tissue damage lesions in CD. Particularly, randomized controlled trials have shown local injections of mesenchymal stem cells to heal perianal fistulas. Conclusion: In a systematic review of mechanisms and treatments of bowel wall damage in patients with CD, we found a need to test drugs that reduce TGFB and increase healing of transmural damage lesions and to pursue research on local injection of mesenchymal stem cells.Show less >

Language :

Anglais

Audience :

Non spécifiée

Popular science :

Non

Administrative institution(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2021-12-08T09:53:52Z
2024-01-31T14:31:12Z