Title :

Water-Soluble Ruthenium (II) Complex Derived From Optically Pure Limonene and Its Microencapsulation Are Efficient Tools Against Bacterial Food Pathogen Biofilms: Escherichia coli, Staphylococcus aureus, Enteroccocus faecalis, and Listeria monocytogenes

Author(s) :

Khelissa, Simon [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
El Fannassi, Yousra [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Mechmechani, Samah [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Alhuthali, Sakhr [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
El Amrani, Mohamed Amin [Auteur]
Université Abdelmalek Essaâdi [UAE]
Gharsallaoui, Adem [Auteur]
Laboratoire d'automatique, de génie des procédés et de génie pharmaceutique [LAGEPP]
Barras, Alexandre [Auteur]
NanoBioInterfaces - IEMN [NBI - IEMN]
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
Chihib, Nour-Eddine [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]

Journal title :

Frontiers in Microbiology

Pages :

711326

Publisher :

Frontiers Media

Publication date :

2021

ISSN :

1664-302X

English keyword(s) :

ruthenium (II)
limonene
complexation
microencapsulation
biofilm
antibacterial agent
food pathogen
biofilm removal

HAL domain(s) :

Chimie/Chimie de coordination
Sciences du Vivant [q-bio]/Ingénierie des aliments
Sciences du Vivant [q-bio]/Microbiologie et Parasitologie/Bactériologie

English abstract : [en]

Bioactive aminooxime ligands based on optically pure (R)-limonene have been synthesized in two steps. Their ruthenium (II) cationic water-soluble complex was prepared by a reaction between dichloro (para-cymene) ruthenium ...
Show more >Bioactive aminooxime ligands based on optically pure (R)-limonene have been synthesized in two steps. Their ruthenium (II) cationic water-soluble complex was prepared by a reaction between dichloro (para-cymene) ruthenium (II) dimers and aminooxime ligands in a 1:2 molar ratio. Antibacterial and antibiofilm activities of the synthetized complex were assessed against Escherichia coli , Staphylococcus aureus , Listeria monocytogenes , and Enterococcus faecalis. The results revealed that the ruthenium (II) complex has higher antibacterial and antibiofilm activities in comparison with free ligands or the enantiopure (R)-limonene. Moreover, microencapsulation of this complex reduced its cytotoxicity and improved their minimum inhibitory concentration and antibiofilm activity toward the considered bacteria. The ruthenium (II) complex targets the bacterial cell membrane, which leads to rapid leakage of intracellular potassium. Our study suggests that the developed ruthenium (II) complexes could be useful as an alternative to conventional disinfectants.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

• Institut d'Électronique, de Microélectronique et de Nanotechnologie (IEMN) - UMR 8520

Source :

Harvested from HAL