Titre :

Chiral Quantum Metamaterial for Hypersensitive Biomolecule Detection

Auteur(s) :

Hajji, Maryam [Auteur]

Cariello, Michele [Auteur]

Gilroy, Cameron [Auteur]

Kartau, Martin [Auteur]

Syme, Christopher D. [Auteur]

Karimullah, Affar [Auteur]

Gadegaard, Nikolaj [Auteur]

Malfait, aurélie [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Woisel, Patrice [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Cooke, Graeme [Auteur]

Peveler, William J. [Auteur]

Kadodwala, Malcolm [Auteur]

Titre de la revue :

ACS Nano

Nom court de la revue :

ACS Nano

Numéro :

15

Pagination :

19905-19916

Éditeur :

American Chemical Society (ACS)

Date de publication :

2021-11-30

ISSN :

1936-0851

Mot(s)-clé(s) en anglais :

superchirality
quantum dots
quantum metamaterials
chiral
plasmonics

Discipline(s) HAL :

Chimie/Matériaux
Chimie/Polymères

Résumé en anglais : [en]

Chiral biological and pharmaceutical molecules are analyzed with phenomena that monitor their very weak differential interaction with circularly polarized light. This inherent weakness results in detection levels for chiral ...
Lire la suite >Chiral biological and pharmaceutical molecules are analyzed with phenomena that monitor their very weak differential interaction with circularly polarized light. This inherent weakness results in detection levels for chiral molecules that are inferior, by at least six orders of magnitude, to the single molecule level achieved by state-of-the-art chirally insensitive spectroscopic measurements. Here, we show a phenomenon based on chiral quantum metamaterials (CQMs) that overcomes these intrinsic limits. Specifically, the emission from a quantum emitter, a semiconductor quantum dot (QD), selectively placed in a chiral nanocavity is strongly perturbed when individual biomolecules (here, antibodies) are introduced into the cavity. The effect is extremely sensitive, with six molecules per nanocavity being easily detected. The phenomenon is attributed to the CQM being responsive to significant local changes in the optical density of states caused by the introduction of the biomolecule into the cavity. These local changes in the metamaterial electromagnetic environment, and hence the biomolecules, are invisible to “classical” light-scattering-based measurements. Given the extremely large effects reported, our work presages next generation technologies for rapid hypersensitive measurements with applications in nanometrology and biodetection.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
CNRS
INRA
ENSCL

Collections :

• Unité Matériaux et Transformations (UMET) - UMR 8207

Équipe(s) de recherche :

Ingénierie des Systèmes Polymères

Date de dépôt :

2022-01-10T08:01:02Z
2022-01-10T10:11:25Z
2024-01-12T12:59:36Z