Title :

Chiral Quantum Metamaterial for Hypersensitive Biomolecule Detection

Author(s) :

Hajji, Maryam [Auteur]

Cariello, Michele [Auteur]

Gilroy, Cameron [Auteur]

Kartau, Martin [Auteur]

Syme, Christopher D. [Auteur]

Karimullah, Affar [Auteur]

Gadegaard, Nikolaj [Auteur]

Malfait, aurélie [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Woisel, Patrice [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Cooke, Graeme [Auteur]

Peveler, William J. [Auteur]

Kadodwala, Malcolm [Auteur]

Journal title :

ACS Nano

Abbreviated title :

ACS Nano

Volume number :

15

Pages :

19905-19916

Publisher :

American Chemical Society (ACS)

Publication date :

2021-11-30

ISSN :

1936-0851

English keyword(s) :

superchirality
quantum dots
quantum metamaterials
chiral
plasmonics

HAL domain(s) :

Chimie/Matériaux
Chimie/Polymères

English abstract : [en]

Chiral biological and pharmaceutical molecules are analyzed with phenomena that monitor their very weak differential interaction with circularly polarized light. This inherent weakness results in detection levels for chiral ...
Show more >Chiral biological and pharmaceutical molecules are analyzed with phenomena that monitor their very weak differential interaction with circularly polarized light. This inherent weakness results in detection levels for chiral molecules that are inferior, by at least six orders of magnitude, to the single molecule level achieved by state-of-the-art chirally insensitive spectroscopic measurements. Here, we show a phenomenon based on chiral quantum metamaterials (CQMs) that overcomes these intrinsic limits. Specifically, the emission from a quantum emitter, a semiconductor quantum dot (QD), selectively placed in a chiral nanocavity is strongly perturbed when individual biomolecules (here, antibodies) are introduced into the cavity. The effect is extremely sensitive, with six molecules per nanocavity being easily detected. The phenomenon is attributed to the CQM being responsive to significant local changes in the optical density of states caused by the introduction of the biomolecule into the cavity. These local changes in the metamaterial electromagnetic environment, and hence the biomolecules, are invisible to “classical” light-scattering-based measurements. Given the extremely large effects reported, our work presages next generation technologies for rapid hypersensitive measurements with applications in nanometrology and biodetection.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CNRS
INRA
ENSCL

Collections :

• Unité Matériaux et Transformations (UMET) - UMR 8207

Research team(s) :

Ingénierie des Systèmes Polymères

Submission date :

2022-01-10T08:01:02Z
2022-01-10T10:11:25Z
2024-01-12T12:59:36Z