Cell-to-cell transmission of p53 aggregates: ...
Document type :
Article dans une revue scientifique
Permalink :
Title :
Cell-to-cell transmission of p53 aggregates: a novel player in oncology?
Author(s) :
Iwahashi, Naoyuki [Auteur]
Ikezaki, Midori [Auteur]
Saito, Hiroyuki [Auteur]
Uchimura, Kenji [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Nishitsuji, Kazuchika [Auteur]
Ikezaki, Midori [Auteur]
Saito, Hiroyuki [Auteur]
Uchimura, Kenji [Auteur]

Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Nishitsuji, Kazuchika [Auteur]
Journal title :
Molecular & Cellular Oncology
Volume number :
8
Pages :
1892444
Publisher :
Taylor & Francis
Publication date :
2021-03-04
ISSN :
2372-3556
English keyword(s) :
p53
protein aggregates
prion
glycosaminoglycan
heparan sulfate
protein aggregates
prion
glycosaminoglycan
heparan sulfate
HAL domain(s) :
Sciences du Vivant [q-bio]
Chimie/Chimie théorique et/ou physique
Chimie/Chimie théorique et/ou physique
English abstract : [en]
The mutants of the tumor suppressor protein p53 form protein aggregates. It has been proposed that these aggregates propagate like prions, albeit the detailed mechanism of the propagation is unclear. Our recent study ...
Show more >The mutants of the tumor suppressor protein p53 form protein aggregates. It has been proposed that these aggregates propagate like prions, albeit the detailed mechanism of the propagation is unclear. Our recent study revealed that sulfated glycosaminoglycans, especially highly sulfated domains of heparan sulfate (heparan sulfate S-domains), participate in cancer pathology by mediating transcellular propagation of p53 aggregates.Show less >
Show more >The mutants of the tumor suppressor protein p53 form protein aggregates. It has been proposed that these aggregates propagate like prions, albeit the detailed mechanism of the propagation is unclear. Our recent study revealed that sulfated glycosaminoglycans, especially highly sulfated domains of heparan sulfate (heparan sulfate S-domains), participate in cancer pathology by mediating transcellular propagation of p53 aggregates.Show less >
Language :
Anglais
Peer reviewed article :
Oui
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Université de Lille
CNRS
CNRS
Research team(s) :
Diversité structurale des héparanes sulfates et régulation de la réponse inflammatoire
Submission date :
2022-01-17T14:30:04Z
2022-01-18T11:52:47Z
2022-01-18T11:52:47Z
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