Th17 cytokines: novel potential therapeutic targets for COPD pathogenesis and exacerbations

Le Rouzic, Olivier; Pichavant, Muriel; Frealle, Emilie; Guillon, Antoine; Si-Tahar, Mustapha; Gosset, Philippe

Document type :

Article dans une revue scientifique

DOI :

10.1183/13993003.02434-2016

PMID :

29025886

Title :

Th17 cytokines: novel potential therapeutic targets for COPD pathogenesis and exacerbations

Author(s) :

Le Rouzic, Olivier [Auteur]

Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Pichavant, Muriel [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Frealle, Emilie [Auteur]

Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Guillon, Antoine [Auteur]
Centre Hospitalier Régional Universitaire de Tours [CHRU Tours]
Centre d’Etude des Pathologies Respiratoires (CEPR), UMR 1100 [CEPR]
Si-Tahar, Mustapha [Auteur]
Centre d’Etude des Pathologies Respiratoires (CEPR), UMR 1100 [CEPR]
Gosset, Philippe [Auteur]

Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]

Journal title :

European Respiratory Journal

Pages :

1602434

Publisher :

European Respiratory Society

Publication date :

2017-10-05

ISSN :

0903-1936

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease of the airways caused mainly by cigarette smoke exposure. COPD progression is marked by exacerbations of the disease, often associated with ...
Show more >Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease of the airways caused mainly by cigarette smoke exposure. COPD progression is marked by exacerbations of the disease, often associated with infections. Recent data show the involvement in COPD pathophysiology of interleukin (IL)-17 and IL-22, two cytokines that are important in the control of lung inflammation and infection. During the initiation and progression of the disease, increased IL-17 secretion causes neutrophil recruitment, leading to chronic inflammation, airways obstruction and emphysema. In the established phase of COPD, a defective IL-22 response facilitates pathogen-associated infections and disease exacerbations. Altered production of these cytokines involves a complex network of immune cells and dysfunction of antigen-presenting cells. In this review, we describe current knowledge on the involvement of IL-17 and IL-22 in COPD pathophysiology at steady state and during exacerbations, and discuss implications for COPD management and future therapeutic approaches.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :