Title :

Analysis of xylitol – citric acid system forming deep eutectic solvent: Application for dissolving poorly water-soluble drugs. A combination of calorimetric and Raman investigations

Author(s) :

Guinet, Yannick [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Paccou, Laurent [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Hedoux, Alain [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207

Journal title :

Journal of Molecular Liquids

Volume number :

318

Pages :

114317

Publisher :

Elsevier

Publication date :

2020-11-15

ISSN :

0167-7322

English keyword(s) :

Milling
Low-wavenumber Raman spectroscopy
Equilibrium phase diagram
Poorly water-soluble drugs
Deep eutectic solvent
Hydrogen-bonded liquids

HAL domain(s) :

Physique [physics]/Matière Condensée [cond-mat]/Science des matériaux [cond-mat.mtrl-sci]
Chimie
Physique [physics]/Matière Condensée [cond-mat]/Matière Molle [cond-mat.soft]
Physique [physics]/Matière Condensée [cond-mat]/Systèmes désordonnés et réseaux de neurones [cond-mat.dis-nn]

English abstract : [en]

The phase diagram of the xylitol – citric acid system was determined from microcalorimetry experiments performed on mixtures prepared by co-milling. Raman investigations in the stretching regions of carbonyl and hydroxyl ...
Show more >The phase diagram of the xylitol – citric acid system was determined from microcalorimetry experiments performed on mixtures prepared by co-milling. Raman investigations in the stretching regions of carbonyl and hydroxyl groups have shown a close relationship between the formation ofmolecular associations between the two molecular species and the drastic negative deviation from ideality for high citric acid content, responsible for obtaining a deep eutectic solvent (DES). Itwas shown that a great amount of poorlywater-soluble drugs (ibuprofen and paracetamol) could be dissolved in that DES, providing a strategy for stabilizing a great amount of amorphous drugs or for obtaining unusual crystalline forms of drugs.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CNRS
INRA
ENSCL

Collections :

• Unité Matériaux et Transformations (UMET) - UMR 8207

Research team(s) :

Matériaux Moléculaires et Thérapeutiques

Submission date :

2022-01-28T10:49:14Z
2022-02-01T11:44:37Z