Titre :

Metabolomic alteration induced by psychotropic drugs: short-term metabolite profile as a predictor of weight gain evolution

Auteur(s) :

Lenski, Marie [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Sidibe, Jonathan [Auteur]
Hôpitaux Universitaires de Genève [HUG]
Gholam, Mehdi [Auteur]
Université de Lausanne = University of Lausanne [UNIL]
Hennart, Benjamin [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Dubath, Celine [Auteur]
Université de Lausanne = University of Lausanne [UNIL]
Augsburger, Marc [Auteur]
Hôpitaux Universitaires de Genève [HUG]
Von Gunten, Armin [Auteur]
Université de Lausanne = University of Lausanne [UNIL]
Conus, Philippe [Auteur]
Université de Lausanne = University of Lausanne [UNIL]
Allorge, Delphine [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Thomas, Aurelien [Auteur]
Hôpitaux Universitaires de Genève [HUG]
Eap, Chin B. [Auteur]
Geneva University Hospital [HUG]
Université de Lausanne = University of Lausanne [UNIL]

Titre de la revue :

Clinical and translational science

Nom court de la revue :

Clin Transl Sci

Date de publication :

2021-08-13

ISSN :

1752-8062

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Psychotropic drugs can induce strong metabolic adverse effects, potentially increasing morbidity and/or mortality of patients. Metabolomic profiling, by studying the levels of numerous metabolic intermediates and products ...
Lire la suite >Psychotropic drugs can induce strong metabolic adverse effects, potentially increasing morbidity and/or mortality of patients. Metabolomic profiling, by studying the levels of numerous metabolic intermediates and products in the blood, allows a more detailed examination of metabolism dysfunctions. We aimed to identify blood metabolomic markers associated with weight gain in psychiatric patients. Sixty-two patients starting a treatment known to induce weight gain were recruited. Two hundred and six selected metabolites implicated in various pathways were analyzed in plasma, at baseline and after 1 month of treatment. Additionally, 15 metabolites of the kynurenine pathway were quantified. This latter analysis was repeated in a confirmatory cohort of 24 patients. Among the 206 metabolites, a plasma metabolomic fingerprint after 1 month of treatment embedded 19 compounds from different chemical classes (amino acids, acylcarnitines, carboxylic acids, catecholamines, nucleosides, pyridine, and tetrapyrrole) potentially involved in metabolic disruption and inflammation processes. The predictive potential of such early metabolite changes on 3 months of weight evolution was then explored using a linear mixed-effects model. Of these 19 metabolites, short-term modifications of kynurenine, hexanoylcarnitine, and biliverdin, as well as kynurenine/tryptophan ratio at 1 month, were associated with 3 months weight evolution. Alterations of the kynurenine pathway were confirmed by quantification, in both exploratory and confirmatory cohorts. Our metabolomic study suggests a specific metabolic dysregulation after 1 month of treatment with psychotropic drugs known to induce weight gain. The identified metabolomic signature could contribute in the future to the prediction of weight gain in patients treated with psychotropic drugs.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
Institut Pasteur de Lille
Université de Lille

Collections :

• IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483

Date de dépôt :

2022-02-02T10:23:15Z
2022-05-10T09:20:33Z
2022-05-24T13:40:31Z