Comparison of in vitro endocrine activity of phthalates and alternative plasticizers

Moche, Helene; Chentouf, Aouatif; Neves, Sergio; Corpart, Jean-Marc; Nesslany, Fabrice

Document type :

Article dans une revue scientifique: Article original

DOI :

10.1155/2021/8815202

PMID :

33628236

Permalink :

http://hdl.handle.net/20.500.12210/59627

Title :

Comparison of in vitro endocrine activity of phthalates and alternative plasticizers

Author(s) :

Moche, Helene [Auteur]
Institut Pasteur de Lille
Chentouf, Aouatif [Auteur]
Neves, Sergio [Auteur]
Corpart, Jean-Marc [Auteur]
Nesslany, Fabrice [Auteur]

IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483

Journal title :

Journal of toxicology

Abbreviated title :

J Toxicol

Volume number :

2021

Pages :

8815202

Publication date :

2021-01-01

ISSN :

1687-8191

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Because of the deleterious effects of phthalates, regulations have been taken to decrease their use, and the needs for alternatives are increasing. Due to the concerns about the endocrine-disrupting properties of phthalates, ...
Show more >Because of the deleterious effects of phthalates, regulations have been taken to decrease their use, and the needs for alternatives are increasing. Due to the concerns about the endocrine-disrupting properties of phthalates, it was deemed necessary to particularly investigate these effects for potential substitutes. In this study, we compared the in vitro endocrine activity of several already used potential alternative plasticizers (DEHT, DINCH, and TOTM) or new substitutes (POLYSORB® isosorbide and POLYSORB® ID 46) to one of 2 phthalates, DEHP and DINP. Effects of these chemicals on 3 common mechanisms of endocrine disruption, i.e., interaction with estrogen receptors (ER), androgen receptors (AR), or steroidogenesis, were studied using extensively used in vitro methods. In the E-Screen assay, only DEHP moderately induced MCF-7 cell proliferation; none of the other tested substances were estrogenic or antiestrogenic. No androgenic or antiandrogenic activity in MDA-kb2 cells was shown for any of the tested phthalates or alternatives. On the other hand, both DEHP and DINP, as well as DEHT, DINCH, and TOTM, disrupted steroidogenesis in the H295R assay, mainly by inducing an increase in estradiol synthesis; no such effect was observed for POLYSORB® isosorbide and POLYSORB® ID 46.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Institut Pasteur de Lille
Université de Lille

Collections :

IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483

Submission date :

2022-02-02T10:23:15Z
2022-08-24T09:24:28Z

Files

Moche et al..pdf
Version éditeur
Open access
Access the document

Except where otherwise noted, this item's license is described as Attribution 3.0 United States

Version	Link	Modification date
2	20.500.12210/59627*	2022-08-24T09:20:34Z
1	20.500.12210/59627.1	2022-02-02T10:23:15Z

Comparison of in vitro endocrine activity ...

BibTeX

CSV

Excel

RIS

Files

Version history

Comparison of in vitro endocrine activity ... BibTeX CSV Excel RIS

Files

Version history

Comparison of in vitro endocrine activity ...

BibTeX

CSV

Excel

RIS