The prognostic impact of cirrhosis on ...
Document type :
Article dans une revue scientifique: Article original
DOI :
PMID :
Permalink :
Title :
The prognostic impact of cirrhosis on patients receiving maintenance haemodialysis
Author(s) :
Artru, Florent [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Louvet, Alexandre [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Glowacki, Francois [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - EA 4483
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Bellati, Sara [Auteur]
498252|||Lille Inflammation Research International Center - U 995 [LIRIC]
Frimat, Marie [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
Gomis, Sebastien [Auteur]
Service de Néphrologie et Transplantation rénale [CHRU-lille]
Castel, Helene [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Barthelon, Justine [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Lassailly, Guillaume [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Dharancy, Sebastien [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Noel, Christian [Auteur]
Service de Néphrologie et Transplantation rénale [CHRU-lille]
Hazzan, Marc [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Mathurin, Philippe [Auteur]
498252|||Lille Inflammation Research International Center - U 995 [LIRIC]

Lille Inflammation Research International Center - U 995 [LIRIC]
Louvet, Alexandre [Auteur]

Lille Inflammation Research International Center - U 995 [LIRIC]
Glowacki, Francois [Auteur]

IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - EA 4483
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Bellati, Sara [Auteur]
498252|||Lille Inflammation Research International Center - U 995 [LIRIC]
Frimat, Marie [Auteur]

Lille Inflammation Research International Center (LIRIC) - U995
Gomis, Sebastien [Auteur]
Service de Néphrologie et Transplantation rénale [CHRU-lille]
Castel, Helene [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Barthelon, Justine [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Lassailly, Guillaume [Auteur]

Lille Inflammation Research International Center - U 995 [LIRIC]
Dharancy, Sebastien [Auteur]

Lille Inflammation Research International Center - U 995 [LIRIC]
Noel, Christian [Auteur]
Service de Néphrologie et Transplantation rénale [CHRU-lille]
Hazzan, Marc [Auteur]

Lille Inflammation Research International Center - U 995 [LIRIC]
Mathurin, Philippe [Auteur]

498252|||Lille Inflammation Research International Center - U 995 [LIRIC]
Journal title :
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
Abbreviated title :
Aliment. Pharmacol. Ther.
Volume number :
50
Pages :
75-83
Publisher :
Wiley Online Library
Publication date :
2019-07
ISSN :
1365-2036
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Further study is needed on the prognostic impact of cirrhosis on haemodialysis patients.
To evaluate cirrhosis' impact according to severity on survival and to provide therapeutic guidelines for haemodialysis cirrhotic ...
Show more >Further study is needed on the prognostic impact of cirrhosis on haemodialysis patients. To evaluate cirrhosis' impact according to severity on survival and to provide therapeutic guidelines for haemodialysis cirrhotic patients. Patients with end-stage renal failure treated with haemodialysis were included retrospectively from 01/01/2000 to 31/12/2004 and prospectively from 01/01/2005 to 31/12/2014 in our French Region. Clinical data, presence of cirrhosis and its severity were recorded at the beginning of haemodialysis. The primary endpoint was 2-year survival. Seven thousand three hundred and fifty-four patients (96%) without cirrhosis and 304 patients (4%) with cirrhosis were included. Two-year survival in noncirrhotic patients was higher than in cirrhotic patients (71.7% vs 54.4%, P < 0.0001). Patients with decompensated cirrhosis had a worse 2-year outcome (44.1%) as compared to compensated cirrhotic (62.8%, P = 0.002) and noncirrhotic patients (71.7%, P < 0.0001). Compensated and decompensated cirrhosis were independent predictive factors of 2-year mortality. In sensitivity analysis restricted to cirrhotic patients, 2-year survival of Child-Pugh A patients was higher than in Child-Pugh B and C patients (65.5% vs 27.7% vs 0%, P < 0.0001). Development of predictive models based either on severity scores (MELD and Child-Pugh) and extrahepatic comorbidities allowed correct classification of around 70% of patients in terms of mortality and may help to better stratify mortality risk in this population. Cirrhosis is independently associated with mortality in haemodialysis patients. Patients with severe cirrhosis have a poor 2-year outcome. Severity of cirrhosis and presence of extrahepatic comorbidities should be considered when deciding to initiate renal replacement therapy.Show less >
Show more >Further study is needed on the prognostic impact of cirrhosis on haemodialysis patients. To evaluate cirrhosis' impact according to severity on survival and to provide therapeutic guidelines for haemodialysis cirrhotic patients. Patients with end-stage renal failure treated with haemodialysis were included retrospectively from 01/01/2000 to 31/12/2004 and prospectively from 01/01/2005 to 31/12/2014 in our French Region. Clinical data, presence of cirrhosis and its severity were recorded at the beginning of haemodialysis. The primary endpoint was 2-year survival. Seven thousand three hundred and fifty-four patients (96%) without cirrhosis and 304 patients (4%) with cirrhosis were included. Two-year survival in noncirrhotic patients was higher than in cirrhotic patients (71.7% vs 54.4%, P < 0.0001). Patients with decompensated cirrhosis had a worse 2-year outcome (44.1%) as compared to compensated cirrhotic (62.8%, P = 0.002) and noncirrhotic patients (71.7%, P < 0.0001). Compensated and decompensated cirrhosis were independent predictive factors of 2-year mortality. In sensitivity analysis restricted to cirrhotic patients, 2-year survival of Child-Pugh A patients was higher than in Child-Pugh B and C patients (65.5% vs 27.7% vs 0%, P < 0.0001). Development of predictive models based either on severity scores (MELD and Child-Pugh) and extrahepatic comorbidities allowed correct classification of around 70% of patients in terms of mortality and may help to better stratify mortality risk in this population. Cirrhosis is independently associated with mortality in haemodialysis patients. Patients with severe cirrhosis have a poor 2-year outcome. Severity of cirrhosis and presence of extrahepatic comorbidities should be considered when deciding to initiate renal replacement therapy.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
CHU Lille
Inserm
Institut Pasteur de Lille
Université de Lille
Inserm
Institut Pasteur de Lille
Université de Lille
Collections :
Submission date :
2022-02-02T10:23:22Z
2023-12-05T07:22:47Z
2023-12-20T09:41:08Z
2023-12-05T07:22:47Z
2023-12-20T09:41:08Z
Files
- Artru et al.pdf
- Version éditeur
- Restricted access
- Access the document