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Prevention of cisplatin-induced acute ...
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Document type :
Article dans une revue scientifique: Article de synthèse/Review paper
DOI :
10.1007/s40265-019-01182-1
PMID :
31429065
Permalink :
http://hdl.handle.net/20.500.12210/59647
Title :
Prevention of cisplatin-induced acute kidney injury: a systematic review and meta-analysis
Author(s) :
Hamroun, Aghiles [Auteur]
Lenain, Remi [Auteur]
Bigna, Jean Joel [Auteur]
Speyer, Elodie [Auteur]
Bui, Linh [Auteur]
Chamley, Paul [Auteur]
Pottier, Nicolas [Auteur] refId
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - EA 4483
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Cauffiez, Christelle [Auteur] refId
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - EA 4483
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Dewaeles, Edmone [Auteur] orcid
Dhalluin, Xavier [Auteur] refId
Thérapies Lasers Assistées par l'Image pour l'Oncologie (ONCO-THAI) - U1189
Thérapies Laser Assistées par l'Image pour l'Oncologie - U 1189 [ONCO-THAI]
SCHERPEREEL, Arnaud [Auteur] refId
Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 8204
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Hazzan, Marc [Auteur] refId
Maanaoui, Mehdi [Auteur]
Service de Néphrologie et Transplantation rénale [CHRU-lille]
Glowacki, Francois [Auteur]
Journal title :
Drugs
Abbreviated title :
Drugs
Publication date :
2019-08-19
ISSN :
1179-1950
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
OBJECTIVE: Cisplatin-induced acute kidney injury (CIA) is a serious adverse event that affects 20-40% of exposed patients, despite any implemented precaution to avoid it. The aim of this work was therefore to identify a ...
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OBJECTIVE: Cisplatin-induced acute kidney injury (CIA) is a serious adverse event that affects 20-40% of exposed patients, despite any implemented precaution to avoid it. The aim of this work was therefore to identify a relevant nephroprotective method for CIA. METHODS: We searched Pubmed, Embase, and Web of Science from 1 January 1978 to 1 June 2018, without language restriction. All studies (observational and interventional) assessing a CIA prevention method for adults receiving at least one course of cisplatin were eligible. The primary outcome was acute nephrotoxicity, as defined by the AKI-KDIGO classification (2012). The odds ratio and corresponding 95% confidence interval were used to assess the associations. We used narrative synthesis in case of heterogeneity regarding intervention, population, or outcome. When possible, a random-effects model was used to pool studies. The heterogeneity between studies was quantified (I2 RESULTS: Within 4520 eligible studies, 51 articles fulfilling the selection criteria were included in the review, assessing 21 different prevention methods. A meta-analysis could only be performed on the 15 observational studies concerning magnesium supplementation (1841 patients), and showed a significant nephroprotective effect for all combined grades of CIA (OR 0.24, [0.19-0.32], I222 CONCLUSIONS: While no method of prevention had so far demonstrated its indisputable efficacy, our results highlight the potential protective effect of magnesium supplementation on cisplatin-induced acute nephrotoxicity. BACKGROUND: This study is registered in PROSPERO, CRD42018090612.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
CHU Lille
CNRS
Inserm
Université de Lille
Collections :
  • IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
  • Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
  • Miniaturisation pour la Synthèse, l'Analyse et la Protéomique (MSAP) - USR 3290
  • Thérapies Lasers Assistées par l'Image pour l'Oncologie (ONCO-THAI) - U1189
Submission date :
2022-02-02T10:23:23Z
Université de Lille

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