Title :

Knockout of receptor for advanced glycation end-products attenuates age-related renal lesions

Author(s) :

Teissier, Thibault [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Quersin, Valentine [Auteur]
Gnemmi, Viviane [Auteur]
Daroux, Maite [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Howsam, Mike [Auteur]
Delguste, Florian [Auteur]
Lemoine, Cecile [Auteur]
Fradin, Chantal [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Schmidt, Ann-Marie [Auteur]
Cauffiez, Christelle [Auteur]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Brousseau, Thierry [Auteur]
Glowacki, Francois [Auteur]
Tessier, Frederic J. [Auteur]
Boulanger, Eric [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Frimat, Marie [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]

Journal title :

Aging cell

Abbreviated title :

Aging Cell

Pages :

e12850

Publication date :

2019-02-22

ISSN :

1474-9726

Keyword(s) :

amyloidosis
renal aging
receptor for AGEs
nephrosclerosis
chronic kidney disease
advanced glycation end-products

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Pro-aging effects of endogenous advanced glycation end-products (AGEs) have been reported, and there is increasing interest in the pro-inflammatory and -fibrotic effects of their binding to RAGE (the main AGE receptor). ...
Show more >Pro-aging effects of endogenous advanced glycation end-products (AGEs) have been reported, and there is increasing interest in the pro-inflammatory and -fibrotic effects of their binding to RAGE (the main AGE receptor). The role of dietary AGEs in aging remains ill-defined, but the predominantly renal accumulation of dietary carboxymethyllysine (CML) suggests the kidneys may be particularly affected. We studied the impact of RAGE invalidation and a CML-enriched diet on renal aging. Two-month-old male, wild-type (WT) and RAGE-/-food-/--/--/--/--/-Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Institut Pasteur de Lille
Université de Lille

Collections :

• Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
• IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
• Miniaturisation pour la Synthèse, l'Analyse et la Protéomique (MSAP) - USR 3290

Submission date :

2022-02-02T10:23:53Z