High level of fluorescent oxidation products ...
Type de document :
Article dans une revue scientifique: Lettre à l'éditeur
PMID :
URL permanente :
Titre :
High level of fluorescent oxidation products and worsening of asthma control over time
Auteur(s) :
Akiki, Zeina [Auteur]
Andrianjafimasy, Miora Valerie [Auteur]
Zerimech, Farid [Auteur]
Institut de Biochimie et Biologie Moléculaire [CHRU Lille]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Le Moual, Nicole [Auteur]
Siroux, Valérie [Auteur]
Dumas, Orianne [Auteur]
Matran, Regis [Auteur]
Université de Lille
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Nadif, Rachel [Auteur]
Andrianjafimasy, Miora Valerie [Auteur]
Zerimech, Farid [Auteur]
Institut de Biochimie et Biologie Moléculaire [CHRU Lille]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Le Moual, Nicole [Auteur]
Siroux, Valérie [Auteur]
Dumas, Orianne [Auteur]
Matran, Regis [Auteur]
Université de Lille
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Nadif, Rachel [Auteur]
Titre de la revue :
Respiratory Research
Nom court de la revue :
Respir. Res.
Numéro :
20
Pagination :
203
Éditeur :
BioMed Central
Date de publication :
2019-09-06
ISSN :
1465-9921
Mot(s)-clé(s) en anglais :
Fluorescent oxidation products
Asthma control
Adult asthma
Longitudinal study
Epidemiology
Oxidative stress
Asthma control
Adult asthma
Longitudinal study
Epidemiology
Oxidative stress
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Sciences du Vivant [q-bio]/Santé publique et épidémiologie
Sciences du Vivant [q-bio]/Santé publique et épidémiologie
Résumé en anglais : [en]
High Fluorescent oxidation products level (FlOPs), a global oxidative stress biomarker, was associated cross-sectionally with poor asthma outcomes but its longitudinal association with asthma evolution has never been ...
Lire la suite >High Fluorescent oxidation products level (FlOPs), a global oxidative stress biomarker, was associated cross-sectionally with poor asthma outcomes but its longitudinal association with asthma evolution has never been examined. We aimed to study the associations between FlOPs level at baseline and changes in current asthma, asthma attacks and asthma control status over 8 years. We used data from the second survey of the French EGEA cohort study as baseline and the third survey as follow-up. At baseline, the mean age of the 489 participants with ever asthma was 39 (± 16) years, 49% were women. Among participants with controlled asthma at baseline, high FlOPs level was significantly associated with worsening of asthma control at follow-up (odds-ratio adjusted for age, sex and smoking status (95% CI): 2.27 (1.32-3.90). No other significant associations were observed. In conclusion, results suggest FlOPs as a predictor of asthma evolution in adults and a good candidate marker in asthma management.Lire moins >
Lire la suite >High Fluorescent oxidation products level (FlOPs), a global oxidative stress biomarker, was associated cross-sectionally with poor asthma outcomes but its longitudinal association with asthma evolution has never been examined. We aimed to study the associations between FlOPs level at baseline and changes in current asthma, asthma attacks and asthma control status over 8 years. We used data from the second survey of the French EGEA cohort study as baseline and the third survey as follow-up. At baseline, the mean age of the 489 participants with ever asthma was 39 (± 16) years, 49% were women. Among participants with controlled asthma at baseline, high FlOPs level was significantly associated with worsening of asthma control at follow-up (odds-ratio adjusted for age, sex and smoking status (95% CI): 2.27 (1.32-3.90). No other significant associations were observed. In conclusion, results suggest FlOPs as a predictor of asthma evolution in adults and a good candidate marker in asthma management.Lire moins >
Langue :
Anglais
Comité de lecture :
Oui
Audience :
Internationale
Vulgarisation :
Non
Projet ANR :
Autre(s) projet(s) ou source(s) de financement :
French Agency for Food, Environmental and Occupational Health & Safety (ANSES/AFSSET, EST- 09–15, PNR-EST 2017)
Merck Sharp & Dohme (MSD)
hospital program of clinical research (PHRC)-Paris
National Research Agency – Health Environment, Health- Work Program (ANR CES-2009)
Région Nord Pas-de-Calais
Merck Sharp & Dohme (MSD)
hospital program of clinical research (PHRC)-Paris
National Research Agency – Health Environment, Health- Work Program (ANR CES-2009)
Région Nord Pas-de-Calais
Établissement(s) :
CHU Lille
Institut Pasteur de Lille
Université de Lille
Institut Pasteur de Lille
Université de Lille
Date de dépôt :
2022-02-02T10:24:07Z
2024-02-21T09:29:48Z
2024-02-21T09:29:48Z
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- Akiki et al.pdf
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