Title :

High level of fluorescent oxidation products and worsening of asthma control over time

Author(s) :

Akiki, Zeina [Auteur]
Andrianjafimasy, Miora Valerie [Auteur]
Zerimech, Farid [Auteur]
Institut de Biochimie et Biologie Moléculaire [CHRU Lille]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Le Moual, Nicole [Auteur]
Siroux, Valérie [Auteur]
Dumas, Orianne [Auteur]
Matran, Regis [Auteur]
Université de Lille
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Nadif, Rachel [Auteur]

Journal title :

Respiratory Research

Abbreviated title :

Respir. Res.

Volume number :

20

Pages :

203

Publisher :

BioMed Central

Publication date :

2019-09-06

ISSN :

1465-9921

English keyword(s) :

Fluorescent oxidation products
Asthma control
Adult asthma
Longitudinal study
Epidemiology
Oxidative stress

HAL domain(s) :

Sciences du Vivant [q-bio]
Sciences du Vivant [q-bio]/Santé publique et épidémiologie

English abstract : [en]

High Fluorescent oxidation products level (FlOPs), a global oxidative stress biomarker, was associated cross-sectionally with poor asthma outcomes but its longitudinal association with asthma evolution has never been ...
Show more >High Fluorescent oxidation products level (FlOPs), a global oxidative stress biomarker, was associated cross-sectionally with poor asthma outcomes but its longitudinal association with asthma evolution has never been examined. We aimed to study the associations between FlOPs level at baseline and changes in current asthma, asthma attacks and asthma control status over 8 years. We used data from the second survey of the French EGEA cohort study as baseline and the third survey as follow-up. At baseline, the mean age of the 489 participants with ever asthma was 39 (± 16) years, 49% were women. Among participants with controlled asthma at baseline, high FlOPs level was significantly associated with worsening of asthma control at follow-up (odds-ratio adjusted for age, sex and smoking status (95% CI): 2.27 (1.32-3.90). No other significant associations were observed. In conclusion, results suggest FlOPs as a predictor of asthma evolution in adults and a good candidate marker in asthma management.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

ANR Project :

Facteurs environnementaux et interactions gène environnnement dans l'asthme et l'allergie

Other project(s) or funding source(s) :

French Agency for Food, Environmental and Occupational Health & Safety (ANSES/AFSSET, EST- 09–15, PNR-EST 2017)
Merck Sharp & Dohme (MSD)
hospital program of clinical research (PHRC)-Paris
National Research Agency – Health Environment, Health- Work Program (ANR CES-2009)
Région Nord Pas-de-Calais

Administrative institution(s) :

CHU Lille
Institut Pasteur de Lille
Université de Lille

Collections :

• IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483

Submission date :

2022-02-02T10:24:07Z
2024-02-21T09:29:48Z