Title :

High level of fluorescent oxidation products and worsening of asthma control over time

Author(s) :

Akiki, Zeina [Auteur]
Andrianjafimasy, Miora Valerie [Auteur]
Zerimech, Farid [Auteur]
Le Moual, Nicole [Auteur]
Siroux, Valerie [Auteur]
Dumas, Orianne [Auteur]
Matran, Regis [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Nadif, Rachel [Auteur]

Journal title :

Respiratory research

Abbreviated title :

Respir. Res.

Volume number :

20

Pages :

203

Publication date :

2019-09-06

ISSN :

1465-993X

Keyword(s) :

Fluorescent oxidation products
Asthma control
Adult asthma
Longitudinal study
Epidemiology
Oxidative stress

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

High Fluorescent oxidation products level (FlOPs), a global oxidative stress biomarker, was associated cross-sectionally with poor asthma outcomes but its longitudinal association with asthma evolution has never been ...
Show more >High Fluorescent oxidation products level (FlOPs), a global oxidative stress biomarker, was associated cross-sectionally with poor asthma outcomes but its longitudinal association with asthma evolution has never been examined. We aimed to study the associations between FlOPs level at baseline and changes in current asthma, asthma attacks and asthma control status over 8 years. We used data from the second survey of the French EGEA cohort study as baseline and the third survey as follow-up. At baseline, the mean age of the 489 participants with ever asthma was 39 (± 16) years, 49% were women. Among participants with controlled asthma at baseline, high FlOPs level was significantly associated with worsening of asthma control at follow-up (odds-ratio adjusted for age, sex and smoking status (95% CI): 2.27 (1.32-3.90). No other significant associations were observed. In conclusion, results suggest FlOPs as a predictor of asthma evolution in adults and a good candidate marker in asthma management.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Institut Pasteur de Lille
Université de Lille

Collections :

• IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483

Submission date :

2022-02-02T10:24:07Z