Title :

Inflammatory and oxidative stress biomarkers induced by silica exposure in crystal craftsmen

Author(s) :

Scalia Carneiro, Ana Paula [Auteur]
Universidade Federal de Minas Gerais = Federal University of Minas Gerais [Belo Horizonte, Brazil] [UFMG]
Algranti, Eduardo [Auteur]
Chérot-Kornobis, Nathalie [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Silva Bezerra, Frank [Auteur]
Tibirica Bon, Ana Maria [Auteur]
Felicidade Tomaz Braz, Nayara [Auteur]
Universidade Federal de Minas Gerais = Federal University of Minas Gerais [Belo Horizonte, Brazil] [UFMG]
Soares Souza, Debora Maria [Auteur]
De Paula Costa, Guilherme [Auteur]
Bussacos, Marco Antonio [Auteur]
De Paula Alvez Bezerra, Olivia Maria [Auteur]
Talvani, Andre [Auteur]

Journal title :

American journal of industrial medicine

Abbreviated title :

Am. J. Ind. Med.

Volume number :

63

Pages :

337-347

Publisher :

Wiley Online Library

Publication date :

2020-01-18

ISSN :

1097-0274

English keyword(s) :

occupational exposure
stone craftsmen
CXCL16
inflammatory biomarkers
silicosis

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Identification of biomarkers associated with the diagnosis and prognosis of silicosis would be highly advantageous in the clinical setting. The aim of this study is to evaluate inflammatory and oxidative stress biomarkers ...
Show more >Identification of biomarkers associated with the diagnosis and prognosis of silicosis would be highly advantageous in the clinical setting. The aim of this study is to evaluate inflammatory and oxidative stress biomarkers in subjects exposed to silica. A cross-sectional study of crystal craftsmen currently (n = 34) or formerly (n = 35) exposed and a group of nonexposed subjects (n = 12) was performed. Personal respirable dust samples were collected. Plasma inflammatory mediators (bone morphogenetic protein- BMP2 and chemokines CXCL16, and CCL5), oxidative stress enzymes (thiobarbituric acid reactive substances [TBARs] and superoxide dismutase [SOD]), and nitrite (NO2- Being currently or formerly exposed to silica was related to increased levels of CXCL16 and TBARs. Currently, exposed subjects showed decreased levels of SOD. Thirty-seven craftsmen with silicosis (26 formerly and 11 currently exposed) showed higher levels of CXCL16, which was positively associated with the radiological severity of silicosis. Compared with the nonexposed, subjects with silicosis had higher levels of TBARs and those with complicated silicosis had lower levels of SOD. In multivariate analysis, higher levels of CXCL16 were associated with exposure status and radiological severity of silicosis. Smoking was not a confounder. FeNO did not distinguish between the exposure status and the presence of silicosis. CXCL16 emerged as a potential biomarker that could distinguish both silica exposure and silicosis. TBARs were elevated in exposed individuals. However, their clinical applications demand further investigation in follow-up studies of representative samples.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Institut Pasteur de Lille
Université de Lille

Collections :

• IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483

Submission date :

2022-02-02T10:24:21Z
2024-02-15T09:17:56Z