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Texture parameters of r2* maps are correlated ...
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Document type :
Article dans une revue scientifique: Article original
DOI :
10.1016/j.neurad.2019.10.004
PMID :
31726073
Permalink :
http://hdl.handle.net/20.500.12210/59749
Title :
Texture parameters of r2* maps are correlated with iron concentration and red blood cells count in clot analogs: a 7t micro-mri study
Author(s) :
Bretzner, Martin [Auteur]
Lopes, Renaud [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 [TCDV]
Mccarthy, Ray [Auteur]
Corseaux, Delphine [Auteur] refId
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Auger, Florent [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 [TCDV]
Gunning, Gillian [Auteur]
Beauval, Nicolas [Auteur] refId
Bongiovanni, Antonino [Auteur]
Tardivel, Meryem [Auteur]
Cordonnier, Charlotte [Auteur] refId
Troubles cognitifs dégénératifs et vasculaires - U 1171 [TCDV]
Pruvo, Jean-Pierre [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 [TCDV]
Susen, Sophie [Auteur] refId
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Leclerc, Xavier [Auteur] refId
Troubles cognitifs dégénératifs et vasculaires - U 1171 [TCDV]
Kuchcinski, Gregory [Auteur] refId
Journal title :
Journal of neuroradiology. Journal de neuroradiologie
Abbreviated title :
J Neuroradiol
Publication date :
2019-11-11
ISSN :
0150-9861
Keyword(s) :
Texture analysis
Clot
Relaxometry
Stroke
MRI
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
OBJECTIVE: Previous studies have suggested that mechanical revascularization in acute ischemic stroke (AIS) patients could be affected by clot histology. In this 7-T micro-MRI study, we used R2* relaxometry of clot analogs ...
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OBJECTIVE: Previous studies have suggested that mechanical revascularization in acute ischemic stroke (AIS) patients could be affected by clot histology. In this 7-T micro-MRI study, we used R2* relaxometry of clot analogs to evaluate the relationship between texture parameters of R2* maps and clot constituents. METHODS: Twelve AIS clot analogs were experimentally generated to obtain a wide range of red blood cell concentrations. All clots underwent a MR acquisition using a 7-T micro-MR system. A 3D multi-echo gradient-echo sequence was performed and R2* maps were generated. First order and second order statistics of R2* histograms within the clots were calculated. Iron concentration in clots was measured using absorption spectrometry and red blood cell count (RBC) was obtained by histopathological analysis. RESULTS: RBC count was strongly correlated with iron concentration within clots (r=0.87, P<.001). Higher RBC count and iron concentration were significantly correlated with first order parameters including: (a) global positive shift of the R2* histogram with higher '10th percentile', 'median', 'mean' and '90th percentile'; (b) increase of the global magnitude of voxel values with higher 'total energy' and 'root mean squared'; (c) greater uniformity of the voxel values with higher 'uniformity' and lower 'entropy'. Second order statistical parameters confirmed that higher RBC count and iron concentration correlated with (a) greater concentration of high gray-level values in the image; (b) more "coarse" texture of R2* maps. CONCLUSIONS: Texture analysis of MRI-R2* maps can accurately estimate the red blood cell count and iron content of AIS clot analogs.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
CHU Lille
Inserm
Institut Pasteur de Lille
Université de Lille
Collections :
  • IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
  • Lille Neurosciences & Cognition (LilNCog) - U 1172
  • Récepteurs nucléaires, Maladies Cardiovasculaires et Diabète (EGID) - U1011
Research team(s) :
Troubles cognitifs dégénératifs et vasculaires
Submission date :
2022-02-02T10:24:35Z
Université de Lille

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