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Extracellular vesicles as actors in the ...
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Document type :
Article dans une revue scientifique: Article original
DOI :
10.1080/10408444.2020.1763252
PMID :
32500824
Permalink :
http://hdl.handle.net/20.500.12210/59750
Title :
Extracellular vesicles as actors in the air pollution related cardiopulmonary diseases
Author(s) :
Alkoussa, Stephanie [Auteur]
Hulo, Sebastien [Auteur] refId
Courcot, Dominique [Auteur]
Billet, Sylvain [Auteur]
Martin, Perrine J. [Auteur]
Journal title :
Critical reviews in toxicology
Abbreviated title :
Crit. Rev. Toxicol.
Pages :
1-22
Publication date :
2020-06-05
ISSN :
1547-6898
Keyword(s) :
air pollutants
particulate matter
lung cancer
COPD
cardiopulmonary diseases
cigarette smoke
Extracellular vesicles
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Many associations were reported between air pollution and daily mortality rates for cardiopulmonary diseases. Humans are exposed to a mixture of oxidizing gases and particles, both anthropogenic and natural. Exposure to ...
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Many associations were reported between air pollution and daily mortality rates for cardiopulmonary diseases. Humans are exposed to a mixture of oxidizing gases and particles, both anthropogenic and natural. Exposure to air toxics causes or exacerbates cardiovascular damages and respiratory diseases. Numerous studies have identified the induction of oxidative stress and sustained inflammatory response as among the main known underlying pathophysiological mechanisms of air pollutants. More recently, the relationship between these mechanisms of action and the secretion of extracellular vesicles (EVs) by lung cells has been revealed. EVs have been shown to be important mediators of cellular communication in the body. The purpose of this review is to first recall the main air pollutants. Then, the cardiopulmonary diseases caused by exposure to air pollution and the pathophysiological mechanisms are presented before showing, through an exhaustive review of the literature, the involvement of EVs in the toxicity of air pollutants and the initiation of cardiopulmonary diseases.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
CHU Lille
Institut Pasteur de Lille
Université de Lille
Collections :
  • IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Submission date :
2022-02-02T10:24:36Z
Université de Lille

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