Title :

Extracellular vesicles as actors in the air pollution related cardiopulmonary diseases

Author(s) :

Alkoussa, Stephanie [Auteur]
Hulo, Sebastien [Auteur]
Courcot, Dominique [Auteur]
Billet, Sylvain [Auteur]
Martin, Perrine J. [Auteur]

Journal title :

Critical reviews in toxicology

Abbreviated title :

Crit. Rev. Toxicol.

Pages :

1-22

Publication date :

2020-06-05

ISSN :

1547-6898

Keyword(s) :

air pollutants
particulate matter
lung cancer
COPD
cardiopulmonary diseases
cigarette smoke
Extracellular vesicles

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Many associations were reported between air pollution and daily mortality rates for cardiopulmonary diseases. Humans are exposed to a mixture of oxidizing gases and particles, both anthropogenic and natural. Exposure to ...
Show more >Many associations were reported between air pollution and daily mortality rates for cardiopulmonary diseases. Humans are exposed to a mixture of oxidizing gases and particles, both anthropogenic and natural. Exposure to air toxics causes or exacerbates cardiovascular damages and respiratory diseases. Numerous studies have identified the induction of oxidative stress and sustained inflammatory response as among the main known underlying pathophysiological mechanisms of air pollutants. More recently, the relationship between these mechanisms of action and the secretion of extracellular vesicles (EVs) by lung cells has been revealed. EVs have been shown to be important mediators of cellular communication in the body. The purpose of this review is to first recall the main air pollutants. Then, the cardiopulmonary diseases caused by exposure to air pollution and the pathophysiological mechanisms are presented before showing, through an exhaustive review of the literature, the involvement of EVs in the toxicity of air pollutants and the initiation of cardiopulmonary diseases.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Institut Pasteur de Lille
Université de Lille

Collections :

• IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483

Submission date :

2022-02-02T10:24:36Z