Title :

Toxicity of iron nanoparticles towards primary cultures of human bronchial epithelial cells

Author(s) :

Canivet, Ludivine [Auteur]
Laboratoire Génie Civil et géo-Environnement (LGCgE) - ULR 4515
Denayer, Franck-Olivier [Auteur]
Laboratoire Génie Civil et géo-Environnement (LGCgE) -EA 4515
Dubot, Pierre [Auteur]
Institut de Chimie et des Matériaux Paris-Est [ICMPE]
Garcon, Guillaume [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Lo Guidice, Jean-Marc [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483

Journal title :

Journal of applied toxicology . JAT

Abbreviated title :

J. Appl. Toxicol.

Volume number :

41

Pages :

203-215

Publisher :

Wiley

Publication date :

2020-08-07

ISSN :

0260-437X

Keyword(s) :

physicochemical characterization
human bronchial epithelial cells
inflammation
iron nanoparticles
oxidative stress
gene expression profiling

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Air pollution is a public health issue and the toxicity of ambient particulate matter (PM) is well-recognized. Although it does not mostly contribute to the total mass of PM, increasing evidence indicates that the ultrafine ...
Show more >Air pollution is a public health issue and the toxicity of ambient particulate matter (PM) is well-recognized. Although it does not mostly contribute to the total mass of PM, increasing evidence indicates that the ultrafine fraction has generally a greater toxicity than the others do. A better knowledge of the underlying mechanisms involved in the pathological disorders related to nanoparticles (NPs) remains essential. Hence, the goal of this study was to determine better whether the exposure to a relatively low dose of well-characterized iron-rich NPs (Fe-NPs) might alter some critical toxicological endpoints in a relevant primary culture model of human bronchial epithelial cells (HBECs). We sought to use Fe-NPs representative of those frequently found in the industrial smokes of metallurgical industries. After having noticed the effective internalization of Fe-NPs, oxidative, inflammatory, DNA repair, and apoptotic endpoints were investigated within HBECs, mainly through transcriptional screening. Taken together, these results revealed that, despite it only produced relatively low levels of reactive oxygen species without any significant oxidative damage, low-dose Fe-NPs quickly significantly deregulated the transcription of some target genes closely involved in the proinflammatory response. Although this inflammatory process seemed to stay under control over time in case of this acute scenario of exposure, the future study of its evolution after a scenario of repeated exposure could be very interesting to evaluate the toxicity of Fe-NPs better.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
IMT Lille Douai
Institut Catholique Lille
Institut Pasteur de Lille
Univ. Artois
Université de Lille

Collections :

• IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
• Laboratoire Génie Civil et géo-Environnement (LGCgE) - ULR 4515

Submission date :

2022-02-02T10:24:37Z
2022-05-25T10:09:06Z