Involuntary 5f-adb-related intoxication following e-cigarette use

Salle, Sophie; Sevestre, Christelle; Richeval, Camille; Hakim, Florian; Allorge, Delphine; Gaulier, Jean-Michel

Type de document :

Article dans une revue scientifique: Article original

DOI :

10.1007/s00414-021-02561-8

PMID :

33765158

URL permanente :

http://hdl.handle.net/20.500.12210/59758

Titre :

Involuntary 5f-adb-related intoxication following e-cigarette use

Auteur(s) :

Salle, Sophie [Auteur]
CIC CHU ( Lille)/inserm
Sevestre, Christelle [Auteur]
Centre Hospitalier Avranches-Granville [CH Avranches-Granville]
Richeval, Camille [Auteur]

IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Hakim, Florian [Auteur]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Allorge, Delphine [Auteur]

IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Gaulier, Jean-Michel [Auteur]

IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483

Titre de la revue :

International journal of legal medicine

Nom court de la revue :

Int J Legal Med

Numéro :

135

Pagination :

1467-1470

Date de publication :

2021-03-25

ISSN :

1437-1596

Mot(s)-clé(s) :

Analytical detection
5F-ADB
Synthetic cannabinoid
E-cigarette
Metabolites

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

The detection of synthetic cannabinoid (SC) intoxication cases is challenging, even more when the involved SC identification is requested in a forensic context. This situation can be complicated by new modes of SC consumption, ...
Lire la suite >The detection of synthetic cannabinoid (SC) intoxication cases is challenging, even more when the involved SC identification is requested in a forensic context. This situation can be complicated by new modes of SC consumption, non-specific symptomatology, and analytical pitfalls. To illustrate these issues, we report the case of a 16-year-old man who presented symptoms evocating of a seizure disorder in the minutes following the use of a friend's e-cigarette. At admission in the emergency department, his electroencephalogram was interpreted as coherent with a recent seizure episode. 5F-ADB, a third generation SC, was detected in the e-liquid and in an early collected (H2 after the e-cigarette use) serum sample (0.50 µg/L), but not in urine samples (H18 and H38). One 5F-ADB metabolite, O-desmethyl-5F-ADB (M5), was detectable in urine up to at least 38 h after intoxication. Neither 5F-ADB nor its metabolites could be detected in victim's hair sampled 3 months after the intoxication. Although leading to a non-specific symptomatology, acute SC intoxication should be considered when the case history is related to e-cigarette or e-liquid use. Early biological samples are recommended, even if analytical screening can be positive for SC metabolites in urine sampled until 2 days after exposure. Accordingly, data from the literature and the present case underscore the relevance of adding both main 5F-ADB metabolites (M5 and 5-OH-pentyl-ADB) to mass spectrum databases used for toxicological screening in order to reduce the risk of false-negative results in intoxication cases involving 5F-ADB.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
Institut Pasteur de Lille
Université de Lille

Collections :

IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483

Date de dépôt :

2022-02-02T10:24:40Z
2022-08-24T09:50:47Z

Fichiers

Salle et al..pdf
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Numéro de version	Lien	Date de modification
2	20.500.12210/59758*	2022-08-24T09:44:54Z
1	20.500.12210/59758.1	2022-02-02T10:24:40Z

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Involuntary 5f-adb-related intoxication ...

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