Title :

Is copd associated with increased risk for microaspiration in intubated critically ill patients ?

Author(s) :

Degroote, Thecle [Auteur]
Groupe Hospitalier Paris Saint-Joseph [hpsj]
Jaillette, Emmanuelle [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Reignier, Jean [Auteur]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Zerimech, Farid [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Girault, Christophe [Auteur]
Service de Soins Intensifs [CHU Rouen]
Université de Rouen Normandie [UNIROUEN]
Brunin, Guillaume [Auteur]
Centre Hospitalier Boulogne-sur-mer
Chiche, Arnaud [Auteur]
Centre Hospitalier Tourcoing
Lacherade, Jean-Claude [Auteur]
Centre Hospitalier Départemental - Hôpital de La Roche-sur-Yon [CHD Vendée]
Mira, Jean-Paul [Auteur]
Hôpital Cochin [AP-HP]
Maboudou, Patrice [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Balduyck, Malika [Auteur]
Maladies Rares du Développement : Génétique, Régulation et Protéomique (RADEME) - ULR 7364
Maladies Rares du Développement : Génétique, Régulation et Protéomique (RADEME) - ULR 7364
Nseir, Saad [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]

Journal title :

Annals of Intensive Care

Abbreviated title :

Ann Intensive Care

Volume number :

11

Pages :

7

Publisher :

SpringerOpen

Publication date :

2021-01-11

ISSN :

2110-5820

Keyword(s) :

Pneumonia
COPD
Intubation
Microaspiration
Mechanical ventilation

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

BACKGROUND: Although COPD patients are at higher risk for aspiration when breathing spontaneously, no information is available on the risk for microaspiration in invasively ventilated COPD patients. The aim of our study ...
Show more >BACKGROUND: Although COPD patients are at higher risk for aspiration when breathing spontaneously, no information is available on the risk for microaspiration in invasively ventilated COPD patients. The aim of our study was to determine the relationship between COPD and abundant microaspiration in intubated critically ill patients. METHODS: This was a retrospective analysis of prospectively collected data, provided by 3 randomized controlled trials on microaspiration in critically ill patients receiving invasive mechanical ventilation for more than 48 h. Abundant microaspiration was defined as the presence of pepsin and or alpha-amylase at significant levels in tracheal aspirates. In all study patients, pepsin and alpha-amylase were quantitatively measured in all tracheal aspirates collected during a 48-h period. COPD was defined using spirometry criteria. RESULTS: Among the 515 included patients, 70 (14%) had proven COPD. Pepsin and alpha-amylase were quantitatively measured in 3873 and 3764 tracheal aspirates, respectively. No significant difference was found in abundant microaspiration rate between COPD and non-COPD patients (62 of 70 patients (89%) vs 366 of 445 (82%) patients, p = 0.25). Similarly, no significant difference was found in abundant microaspiration of gastric contents (53% vs 45%, p = 0.28), oropharyngeal secretions (71% vs 71%, p = 0.99), or VAP (19% vs 22%, p = 0.65) rates between the two groups. No significant difference was found between COPD and non-COPD patients in duration of mechanical ventilation, ICU length of stay, or ICU mortality. CONCLUSIONS: Our results suggest that COPD is not associated with increased risk for abundant microaspiration in intubated critically ill patients.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Institut Pasteur de Lille
Université de Lille

Collections :

• IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
• Maladies Rares du Développement : Génétique, Régulation et Protéomique (RADEME) - ULR 7364

Submission date :

2022-02-02T10:24:48Z
2022-05-25T09:14:41Z