Mutagenicity and genotoxicity assessments ...
Type de document :
Article dans une revue scientifique: Article original
PMID :
URL permanente :
Titre :
Mutagenicity and genotoxicity assessments of some industrially processed meat products in algeria
Auteur(s) :
Chamlal, Naima [Auteur]
Benouareth, Djamel Eddine [Auteur]
Khallef, Messaouda [Auteur]
Simar-Mentieres, Sophie [Auteur]
Institut Pasteur de Lille
Nesslany, Fabrice [Auteur]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Benouareth, Djamel Eddine [Auteur]
Khallef, Messaouda [Auteur]
Simar-Mentieres, Sophie [Auteur]
Institut Pasteur de Lille
Nesslany, Fabrice [Auteur]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Titre de la revue :
Toxicology in vitro . an international journal published in association with BIBRA
Nom court de la revue :
Toxicol In Vitro
Numéro :
73
Pagination :
105145
Éditeur :
Elsevier
Date de publication :
2021-03-15
ISSN :
1879-3177
Mot(s)-clé(s) :
Mutagenicity
Ames test
In vitro micronucleus assay
Industrially processed meat
Genotoxicity
Ames test
In vitro micronucleus assay
Industrially processed meat
Genotoxicity
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Processed meat products are presumptive sources of mutagens and genotoxins for consumers. Several epidemiological studies have reported that these products' high intakes have a positive link with cancer incidence. In ...
Lire la suite >Processed meat products are presumptive sources of mutagens and genotoxins for consumers. Several epidemiological studies have reported that these products' high intakes have a positive link with cancer incidence. In Algeria, industrially processed meat products are widely consumed. However, there are no earlier studies involving their genotoxic activity. For this end, the current study aimed at evaluating the mutagenicity and the genotoxicity of some representative industrially processed meat products sold in popular supermarkets. All samples were extracted by established method, using both polar and non-polar solvents. The meat extracts mutagenicity was assessed by Ames test, using four strains of Salmonella typhimurium in the presence and absence of metabolic activation, and subsequently by treat and wash assay for extracts showing biologically significant results. The genotoxicity was determined in TK6 human lymphoblastoid cells using the in vitro micronucleus assay in micromethod. The results showed that all extracts analyzed induce no mutagenic activity. However, one of these extracts induced a biologically significant increase in the number of micronucleated cells. Our findings indicate the importance of the genetic damage detection for taking measures to suppress or reduce the exposure to harmful contaminants and encourage further research investigating genotoxic effects of industrially processed meat worldwide.Lire moins >
Lire la suite >Processed meat products are presumptive sources of mutagens and genotoxins for consumers. Several epidemiological studies have reported that these products' high intakes have a positive link with cancer incidence. In Algeria, industrially processed meat products are widely consumed. However, there are no earlier studies involving their genotoxic activity. For this end, the current study aimed at evaluating the mutagenicity and the genotoxicity of some representative industrially processed meat products sold in popular supermarkets. All samples were extracted by established method, using both polar and non-polar solvents. The meat extracts mutagenicity was assessed by Ames test, using four strains of Salmonella typhimurium in the presence and absence of metabolic activation, and subsequently by treat and wash assay for extracts showing biologically significant results. The genotoxicity was determined in TK6 human lymphoblastoid cells using the in vitro micronucleus assay in micromethod. The results showed that all extracts analyzed induce no mutagenic activity. However, one of these extracts induced a biologically significant increase in the number of micronucleated cells. Our findings indicate the importance of the genetic damage detection for taking measures to suppress or reduce the exposure to harmful contaminants and encourage further research investigating genotoxic effects of industrially processed meat worldwide.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
CHU Lille
Institut Pasteur de Lille
Université de Lille
Institut Pasteur de Lille
Université de Lille
Date de dépôt :
2022-02-02T10:24:52Z
2022-05-25T08:58:10Z
2022-05-25T09:32:38Z
2022-05-25T09:35:58Z
2022-05-25T08:58:10Z
2022-05-25T09:32:38Z
2022-05-25T09:35:58Z
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