Title :

Clinical relevance of serum kyn/trp ratio and basal and ifn?-upregulated ido1 expression in peripheral monocytes in early stage melanoma

Author(s) :

Meireson, Annabel [Auteur]
Universiteit Gent = Ghent University [UGENT]
Ghent University Hospital
Ferdinande, Liesbeth [Auteur]
Ghent University Hospital
Haspeslagh, Marc [Auteur]
Universiteit Gent = Ghent University [UGENT]
Ghent University Hospital
Hennart, Benjamin [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Allorge, Delphine [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Ost, Piet [Auteur]
Universiteit Gent = Ghent University [UGENT]
Ghent University Hospital
Sundahl, Nora [Auteur]
Universiteit Gent = Ghent University [UGENT]
Ghent University Hospital
Spaas, Mathieu [Auteur]
Universiteit Gent = Ghent University [UGENT]
Ghent University Hospital
Demeyer, Annelies [Auteur]
Universiteit Gent = Ghent University [UGENT]
Ghent University Hospital
Brochez, Lieve [Auteur]
Universiteit Gent = Ghent University [UGENT]
Ghent University Hospital

Journal title :

Frontiers in Immunology

Abbreviated title :

Front Immunol

Volume number :

12

Pages :

736498

Publication date :

2021-09

ISSN :

1664-3224

English keyword(s) :

early stage melanoma
biomarker
IDO1
Kyn/Trp
tryptophan metabolism
monocytes
immune cells
liquid biopsy

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Immune escape is an early phenomenon in cancer development/progression. Indoleamine 2,3-dioxygenase 1 (IDO1) is a normal endogenous mechanism of acquired peripheral immune tolerance and may therefore be tumor-promoting. ...
Show more >Immune escape is an early phenomenon in cancer development/progression. Indoleamine 2,3-dioxygenase 1 (IDO1) is a normal endogenous mechanism of acquired peripheral immune tolerance and may therefore be tumor-promoting. This study investigated the clinical relevance of IDO1 expression by immune cells in the lymph nodes and blood and of the serum kynurenine/tryptophan (Kyn/Trp) ratio in 65 systemic treatment naïve stage I-III melanoma patients. Blood samples were collected within the first year of diagnosis. Patients had a median follow-up of 61 months. High basal IDO1 expression in peripheral monocytes and low IFNγ-induced IDO1 upregulation correlated with worse outcome independent from disease stage. Interestingly studied factors were not interrelated. During follow-up, the risk of relapse was 9% (2/22) in the subgroup with high IFNγ-induced IDO1 upregulation in monocytes. In contrast, if IDO1 upregulation was low, relapse occurred in 30% (3/10) of patients with low basal IDO1 expression in monocytes and in 61.5% (8/13) in the subgroup with high basal IDO1 expression in monocytes (Log-Rank test, p=0.008). This study reveals some immune features in the blood of early stage melanoma that may be of relevance for disease outcome. These may offer a target for sub-stratification and early intervention.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Institut Pasteur de Lille
Université de Lille

Collections :

• IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483

Submission date :

2022-02-02T10:25:04Z
2022-05-24T11:54:06Z