Title :

Renal impairment assessment on adults living nearby a landfill: early kidney dysfunction biomarkers linked to the environmental exposure to heavy metals

Author(s) :

Cabral, Mathilde [Auteur]
Unité de Chimie Environnementale et Interactions sur le Vivant [UCEIV]
Université du Littoral Côte d'Opale [ULCO]

Garcon, Guillaume [Auteur]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Toure, Aminata [Auteur]

Bah, Fatoumata [Auteur]

Dewaele, Dorothee [Auteur]
Centre commun de mesures [CCM-ULCO]
Bouhsina, Saad [Auteur]
Unité de Chimie Environnementale et Interactions sur le Vivant [UCEIV]
Université du Littoral Côte d'Opale [ULCO]
Cazier, Fabrice [Auteur]
Centre commun de mesures [CCM-ULCO]
Faye, Adama [Auteur]

Fall, Mamadou [Auteur]

Courcot, Dominique [Auteur]
Unité de Chimie Environnementale et Interactions sur le Vivant [UCEIV]
Université du Littoral Côte d'Opale [ULCO]
Verdin, Anthony [Auteur]
Unité de Chimie Environnementale et Interactions sur le Vivant [UCEIV]
Université du Littoral Côte d'Opale [ULCO]

Journal title :

Toxicology reports

Abbreviated title :

Toxicol Rep

Volume number :

8

Pages :

386-394

Publication date :

2021-02-18

ISSN :

2214-7500

English keyword(s) :

Biomarkers
Cadmium
Landfill
Lead
Population
Nephrotoxicity

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

The aim of this study was to assess the integrity and kidney overall functional capacity of subjects exposed to landfill emissions. Urine and blood levels of Pb and Cd, and several of the newly biomarkers of nephrotoxicity ...
Show more >The aim of this study was to assess the integrity and kidney overall functional capacity of subjects exposed to landfill emissions. Urine and blood levels of Pb and Cd, and several of the newly biomarkers of nephrotoxicity (Kim Injury Molecule 1 (KIM-1), alpha-1 Microglobulin (α1 M), beta-2 Microglobulin (β2 M), Cystatin-C (Cyst C), Clusterin, alpha-glutathione S-transferase (GSTα), pi-glutathione S-transferase (GSTπ), Tissue Inhibitor of Metalloproteinase-1 (TIMP1), Calbindin, Neutrophil Gelatinase-Associated Lipocalin (NGAL), Osteopontin (OPN), (Retinol Binding Protein(RBP), Liver-type Fatty Acid-Binding Protein (FABP-1), Trefoil Factor 3 (TFF3), Collagen VI) were measured in order to assess glomerular and tubule damage in adults living near a landfill. Our results indicate glomerular dysfunction in exposed subjects, and supported evidence of necrosis of proximal and distal tubule epithelial cells as specific biomarkers began to appear in the urine. Positive correlation by Pearson test were obtained between : blood Pb and B-OPN, B-Cyst C, Calbindin, U-KIM-1, TIMP1, U-OPN, and U-Clusterin; and also, between urinary Cd and TIMP1, B-Clusterin, U-OPN, FABP-1, Albumin, and U-Clusterin. The relation between biomarkers of Cd/Pb exposure and early effect biomarkers in this study clearly predicts the future risk of severe kidney injury in subjects living close to the landfill.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Institut Pasteur de Lille
Université de Lille

Collections :

• IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483

Submission date :

2022-02-02T10:25:05Z
2022-05-24T12:52:57Z