Title :

Spectroscopic characterization of single co-crystal of mefenamic acid and nicotinamide using supercritical CO2

Author(s) :

Vaksler, Ye.A. [Auteur]
V.N. Karazin Kharkiv National University [KhNU]
Institute for Single Crystals, National Academy of Science (NAS) of Ukraine [SSI ]
Laboratoire Avancé de Spectroscopie pour les Intéractions la Réactivité et l'Environnement - UMR 8516 [LASIRE]
Benedis, D. [Auteur]
V.N. Karazin Kharkiv National University [KhNU]
Laboratoire Avancé de Spectroscopie pour les Intéractions la Réactivité et l'Environnement - UMR 8516 [LASIRE]
Dyshin, A.A. [Auteur]
Oparin, R.D. [Auteur]
Institute of Solution Chemistry [Ivanovo] [ISC]
T. Correia, Natália [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Capet, Frederic [Auteur]
Unité de Catalyse et Chimie du Solide (UCCS) - UMR 8181
Shishkina, S.V. [Auteur]
V.N. Karazin Kharkiv National University [KhNU]
Kiselev, M.G. [Auteur]
Institute of Solution Chemistry [Ivanovo] [ISC]
Idrissi, A. [Auteur]
Laboratoire Avancé de Spectroscopie pour les Intéractions la Réactivité et l'Environnement - UMR 8516 [LASIRE]

Journal title :

Journal of Molecular Liquids

Abbreviated title :

Journal of Molecular Liquids

Volume number :

334

Pages :

116117

Publication date :

2021-07-15

ISSN :

01677322

HAL domain(s) :

Physique [physics]/Matière Condensée [cond-mat]/Science des matériaux [cond-mat.mtrl-sci]
Physique [physics]/Matière Condensée [cond-mat]/Matière Molle [cond-mat.soft]
Physique [physics]/Matière Condensée [cond-mat]/Systèmes désordonnés et réseaux de neurones [cond-mat.dis-nn]

English abstract : [en]

The present study explores the possibility to synthetize, using supercritical fluid, single crystal of co-crystal formed by mefenamic acid as active pharmaceutical ingredient and nicotinamide as a co-former. The growth of ...
Show more >The present study explores the possibility to synthetize, using supercritical fluid, single crystal of co-crystal formed by mefenamic acid as active pharmaceutical ingredient and nicotinamide as a co-former. The growth of single crystals is important for the determination of co-crystal structure and in particular, for the ones whose unit cells contain a large number of atoms, it becomes crucial. For this purpose, we analyzed the effect of temperature, solid mixture composition and time duration of the co-crystallization process on the synthetized solid. The structure of the latter was determined using single-crystal X-ray diffraction while the composition of fine powders and the intermolecular interactions involved in their synthesis were analyzed using powder X-ray diffraction and diffuse reflectance infrared Fourier transform spectroscopy respectively. Our results show that the single crystal of mefenamic acid and nicotinamide co-crystal is synthetized for the first time in supercritical CO2 at 90 °C, 193 bars and a time duration of three weeks.Show less >

Language :

Anglais

Audience :

Non spécifiée

Popular science :

Non

Administrative institution(s) :

CNRS
Centrale Lille
ENSCL
INRA
Univ. Artois
Université de Lille

Collections :

• Unité de Catalyse et Chimie du Solide (UCCS) - UMR 8181
• Unité Matériaux et Transformations (UMET) - UMR 8207

Research team(s) :

Matériaux Moléculaires et Thérapeutiques

Submission date :

2022-03-24T09:02:32Z
2023-11-15T11:29:14Z